A ratiometric fluorescent probe based on a BODIPY-DCDHF conjugate for the detection of hypochlorous acid in living cells

被引:110
作者
Park, Jeesook [1 ]
Kim, Hyunjin [2 ]
Choi, Yongdoo [2 ]
Kim, Youngmi [1 ]
机构
[1] Dankook Univ, Inst Nanosensor & Biotechnol, Dept Chem, Yongin 448701, Gyeonggi Do, South Korea
[2] Natl Canc Ctr, Mol Imaging & Therapy Branch, Goyang Si 410769, Gyeonggi Do, South Korea
关键词
HUMAN ATHEROSCLEROTIC LESIONS; MYELOPEROXIDASE; INFLAMMATION; MACROPHAGES; OXIDATION; CATALYST; STRESS;
D O I
10.1039/c3an36820c
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A colorimetric and ratiometric fluorescent probe consisting of a boron-dipyrromethene (BODIPY) dye conjugated with a 2-dicyanomethylene-3-cyano-2,5-dihydrofuran (DCDHF) group has been designed for the selective and sensitive detection of HOCl/OCl- via oxidative cleavage of an alkene linker between BODIPY and DCDHF.
引用
收藏
页码:3368 / 3371
页数:4
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