Core-Shell Structures of Oligosaccharide-Functionalized Hyperbranched Poly(ethylene imines)

被引：15
作者：
Thuenemann, Andreas F. [1 ]
Bienert, Ralf [1 ]
Appelhans, Dietmar [2 ]
Voit, Brigitte [2 ]
机构：
[1] BAM Fed Inst Mat Res & Testing, D-12489 Berlin, Germany
[2] Leibniz Inst Polymer Res Dresden, D-01069 Dresden, Germany
来源：
MACROMOLECULAR CHEMISTRY AND PHYSICS | 2012年 / 213卷 / 22期
关键词：
colloids; core-shell polymers; nanoparticles; polyamines; small-angle X-ray scattering (SAXS); BIOLOGICAL-PROPERTIES; DENDRIMERS; NANOPARTICLES; POLYETHYLENEIMINE; GLYCODENDRIMERS; POLYMER; MALTOSE; PEI; DNA;
D O I：
10.1002/macp.201100490
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Hyperbranched poly(ethylene imine)s (PEIs) functionalized with maltose, maltotriose, and maltoheptaose form distinct core-shell globular nanoparticles as revealed by small-angle X-ray scattering (SAXS). The solution structures are quantified using the Beaucage unified exponential/power-law approach. SAXS results were confirmed with dynamic light scattering (DLS). We found that all PEI structures are completely insensitive to changes of temperature (5 degrees C < T < 80 degrees C) and pH (1 < pH < 10). This remarkable stability of a compact spherical polymeric structure makes the modified PEIs promising for a wide range of biomedical applications.
引用
收藏
页码：2362 / 2369
页数：8
相关论文
共 39 条
[1]   Dense-shell glycodendrimers: UV/Vis and electron paramagnetic resonance study of metal ion complexation [J].
Appelhans, Dietmar ;
Oertel, Ulrich ;
Mazzeo, Roberto ;
Komber, Hartmut ;
Hoffmann, Jan ;
Weidner, Steffen ;
Brutschy, Bernhard ;
Voit, Brigitte ;
Ottaviani, Maria Francesca .
PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 2010, 466 (2117) :1489-1513
[2]   Hyperbranched PEI with Various Oligosaccharide Architectures: Synthesis, Characterization, ATP Complexation, and Cellular Uptake Properties [J].
Appelhans, Dietmar ;
Komber, Hartmut ;
Quadir, Mohiuddin Abdul ;
Richter, Sven ;
Schwarz, Simona ;
van der Vlist, Jereon ;
Aigner, Achim ;
Mueller, Martin ;
Loos, Katja ;
Seidel, Juergen ;
Arndt, Karl-Friedrich ;
Haag, Rainer ;
Voit, Brigitte .
BIOMACROMOLECULES, 2009, 10 (05) :1114-1124
[3]   Enhancement of gene transfer activity mediated by mannosylated dendrimer/α-cyclodextrin conjugate (generation 3, G3) [J].
Arima, Hidetoshi ;
Chihara, Yuko ;
Arizono, Masayo ;
Yamashita, Shogo ;
Wada, Koki ;
Hirayama, Fumitoshi ;
Uekama, Kaneto .
JOURNAL OF CONTROLLED RELEASE, 2006, 116 (01) :64-74
[4]   Dendrimers in solution: Insight from theory and simulation [J].
Ballauff, M ;
Likos, CN .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (23) :2998-3020
[5]   Approximations leading to a unified exponential power-law approach to small-angle scattering [J].
Beaucage, G .
JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1995, 28 :717-728
[6]   Characterization of interactions in aqueous solutions of hydroxyethylcellulose and its hydrophobically modified analogue in the presence of a cyclodextrin derivative [J].
Beheshti, N ;
Bu, H ;
Zhu, KZ ;
Kjoniksen, AL ;
Knudsen, KD ;
Pamies, R ;
Cifre, JGH ;
de la Torre, JG ;
Nyström, B .
JOURNAL OF PHYSICAL CHEMISTRY B, 2006, 110 (13) :6601-6608
[7]   Dendrimers in drug research [J].
Boas, U ;
Heegaard, PMH .
CHEMICAL SOCIETY REVIEWS, 2004, 33 (01) :43-63
[8]   Polysaccharide-Based Polyelectrolyte Complex Nanoparticles from Chitosan, Heparin, and Hyaluronan [J].
Boddohi, Soheil ;
Moore, Nicholas ;
Johnson, Patrick A. ;
Kipper, Matt J. .
BIOMACROMOLECULES, 2009, 10 (06) :1402-1409
[9]   Recent trends in glycodendrimer syntheses and applications [J].
Chabre, Yoann M. ;
Roy, Rene .
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2008, 8 (14) :1237-1285
[10]   Hyperbranched glycoconjugated polymer from natural small molecule kanamycin as a safe and efficient gene vector [J].
Chen, Mingsheng ;
Wu, Jieli ;
Zhou, Linzhu ;
Jin, Chengyu ;
Tu, Chunlai ;
Zhu, Bangshang ;
Wu, Fuan ;
Zhu, Qi ;
Zhu, Xinyuan ;
Yan, Deyue .
POLYMER CHEMISTRY, 2011, 2 (11) :2674-2682
1234