Clinical Outcomes of a Zika Virus Mother-Child Pair Cohort in Spain

被引：6

作者：

Soriano-Arandes, Antoni ^{[1
]}

Antoinette Frick, Marie ^{[1
]}

Garcia Lopez-Hortelano, Milagros ^{[2
]}

Sulleiro, Elena ^{[3
]}

Rodo, Carlota ^{[4
]}

Paz Sanchez-Seco, Maria ^{[5
]}

Cabrera-Lafuente, Marta ^{[6
]}

Suy, Anna ^{[4
]}

De la Calle, Maria ^{[7
]}

Santos, Mar ^{[8
]}

Antolin, Eugenia ^{[7
]}

del Carmen Vinuela, Maria ^{[9
]}

Espiau, Maria ^{[1
]}

Salazar, Ainara ^{[1
]}

Guarch-Ibanez, Borja ^{[10
]}

Vazquez, Ana ^{[5
]}

Navarro-Moron, Juan ^{[11
]}

Ramos-Amador, Jose-Tomas ^{[12
]}

Martin-Nalda, Andrea ^{[1
]}

Duenas, Eva ^{[8
]}

Blazquez-Gamero, Daniel ^{[13
,14
]}

Reques-Cosme, Resurreccion ^{[15
]}

Olabarrieta, Iciar ^{[16
]}

Prieto, Luis ^{[13
,14
]}

De Ory, Fernando ^{[5
]}

Thorne, Claire ^{[17
]}

Byrne, Thomas ^{[17
]}

Ades, Anthony E. ^{[18
]}

Ruiz-Burga, Elisa ^{[17
]}

Giaquinto, Carlo ^{[19
]}

Jose Mellado-Pena, Maria ^{[2
]}

Garcia-Alix, Alfredo ^{[20
]}

Carreras, Elena ^{[4
]}

Soler-Palacin, Pere ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Vall dHebron Res Inst, Paediat Infect Dis & Immunodeficiencies Unit, Barcelona 08035, Spain

[2] Hosp Univ La Paz, Dept Paediat, Madrid 28046, Spain

[3] Hosp Univ Vall dHebron, Dept Microbiol, Barcelona 08035, Spain

[4] Hosp Univ Vall dHebron, Dept Obstet, Unit Fetal Med, Barcelona 08035, Spain

[5] Inst Salud Carlos III, Madrid 28029, Spain

[6] Hosp Univ La Paz, Dept Neonatol, Madrid 28046, Spain

[7] Hosp Univ La Paz, Dept Obstet, Madrid 28046, Spain

[8] Hosp Gen Univ Gregorio Maranon, Dept Paediat, Madrid 28009, Spain

[9] Hosp Gen Univ Gregorio Maranon, Dept Obstet, Madrid 28009, Spain

[10] Hosp Univ Josep Trueta, Dept Paediat, Girona 17007, Spain

[11] Hosp Costa del Sol, Marbella 29603, Spain

[12] Hosp Univ Clin San Carlos, Dept Paediat, Madrid 28040, Spain

[13] Hosp Univ 12 Octubre, Pediat Infect Dis Unit, Madrid, Spain

[14] Univ Complutense, Imas12, Inst Invest Hosp 12 Octubre, Madrid 28041, Spain

[15] Hosp El Escorial, Madrid 28200, Spain

[16] Hosp Severo Ochoa, Madrid 28911, Spain

[17] Univ Coll London Great Ormond St Inst Child Hlth, GOSH NIHR BRC, London WC1N 1EH, England

[18] Univ Bristol, Bristol BS9 1AF, Avon, England

[19] Univ Padua, Dept Woman & Child Hlth, Div Pediat Infect Dis, I-35122 Padua, Italy

[20] Fundacio NeNe, Madrid 28010, Spain

来源：

PATHOGENS | 2020年 / 9卷 / 05期

基金：

英国医学研究理事会; 欧盟地平线“2020”;

关键词：

zika virus; microcephaly; congenital infection; adverse outcome; arboviruses; INFECTION; INFANTS;

D O I：

10.3390/pathogens9050352

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4-6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4-39.6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations.

引用

页数：14

共 26 条

[1] Infant outcomes among women with Zika virus infection during pregnancy: results of a large prenatal Zika screening program [J].

Adhikari, Emily H. ;

Nelson, David B. ;

Johnson, Kathryn A. ;

Jacobs, Sara ;

Rogers, Vanessa L. ;

Roberts, Scott W. ;

Sexton, Taylor ;

McIntire, Donald D. ;

Casey, Brian M. .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2017, 216 (03) :292.e1-292.e8

[2]

[Anonymous], B ECEMC REV DISMORFO

[3]

[Anonymous], 2017, PROC MAN INF VIR ZIK

[4]

Bailey DB, 2018, PEDIATRICS, V141, pS180, DOI [10.1542/peds.2017-2038G, 10.1542/peds.2017-2038g]

[5] Zika Virus Infection in Pregnant Women in Rio de Janeiro [J].

Brasil, P. ;

Pereira, J. P., Jr. ;

Moreira, M. E. ;

Ribeiro Nogueira, R. M. ;

Damasceno, L. ;

Wakimoto, M. ;

Rabello, R. S. ;

Valderramos, S. G. ;

Halai, U. -A. ;

Salles, T. S. ;

Zin, A. A. ;

Horovitz, D. ;

Daltro, P. ;

Boechat, M. ;

Gabaglia, C. Raja ;

Carvalho de Sequeira, P. ;

Pilotto, J. H. ;

Medialdea-Carrera, R. ;

Cotrim da Cunha, D. ;

Abreu de Carvalho, L. M. ;

Pone, M. ;

Machado Siqueira, A. ;

Calvet, G. A. ;

Rodrigues Baiao, A. E. ;

Neves, E. S. ;

Nassar de Carvalho, P. R. ;

Hasue, R. H. ;

Marschik, P. B. ;

Einspieler, C. ;

Janzen, C. ;

Cherry, J. D. ;

Bispo de Filippis, A. M. ;

Nielsen-Saines, K. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (24) :2321-2334

[6]

Conners EE, 2018, OBSTET GYNECOL, V132, P487, DOI [10.1097/AOG.0000000000002737, 10.1097/aog.0000000000002737]

[7] Defining the syndrome associated with congenital Zika virus infection [J].

Costello, Anthony ;

Dua, Tarun ;

Duran, Pablo ;

Gulmezoglu, Metin ;

Oladapo, Olufemi T. ;

Perea, William ;

Pires, Joao ;

Ramon-Pardo, Pilar ;

Rollins, Nigel ;

Saxena, Shekhar .

BULLETIN OF THE WORLD HEALTH ORGANIZATION, 2016, 94 (06) :406-406

[8] The phenotypic spectrum of congenital Zika syndrome [J].

del Campo, Miguel ;

Feitosa, Ian M. L. ;

Ribeiro, Erlane M. ;

Horovitz, Dafne D. G. ;

Pessoa, Andre L. S. ;

Franca, Giovanny V. A. ;

Garcia-Alix, Alfredo ;

Doriqui, Maria J. R. ;

Wanderley, Hector Y. C. ;

Sanseverino, Maria V. T. ;

Neri, Joao I. C. F. ;

Pina-Neto, Joao M. ;

Santos, Emerson S. ;

Vercosa, Islane ;

Cernach, Mirlene C. S. P. ;

Medeiros, Paula F. V. ;

Kerbage, Saile C. ;

Silva, Andre A. ;

van der Linden, Vanessa ;

Martelli, Celina M. T. ;

Cordeiro, Marli T. ;

Dhalia, Rafael ;

Vianna, Fernanda S. L. ;

Victora, Cesar G. ;

Cavalcanti, Denise P. ;

Schuler-Faccini, Lavinia .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2017, 173 (04) :841-857

[9] Early detection of neonatal hearing loss by otoacoustic emissions and auditory brainstem response over 10 years of experience [J].

Escobar-Ipuz, Fredy A. ;

Soria-Bretones, Carmen ;

Garcia-Jimenez, Maria A. ;

Cueto, Elisa M. ;

Torres Aranda, Ana M. ;

Mateo Sotos, Jorge .

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 2019, 127

[10] Zika virus impairs growth in human neurospheres and brain organoids [J].

Garcez, Patricia P. ;

Loiola, Erick Correia ;

da Costa, Rodrigo Madeiro ;

Higa, Luiza M. ;

Trindade, Pablo ;

Delvecchio, Rodrigo ;

Nascimento, Juliana Minardi ;

Brindeiro, Rodrigo ;

Tanuri, Amilcar ;

Rehen, Stevens K. .

SCIENCE, 2016, 352 (6287) :816-818

← 1 2 3 →