The carcinoembryonic antigen (CEA) family:: structures, suggested functions and expression in normal and malignant tissues

被引：998
作者：
Hammarström, S [1 ]
机构：
[1] Umea Univ, Dept Immunol, SE-90185 Umea, Sweden
来源：
SEMINARS IN CANCER BIOLOGY | 1999年 / 9卷 / 02期
关键词：
carcinoembryonic antigen (CEA); biliary glycoprotein (BGP); non-specific cross-reacting antigen (NCA) pregnancy specific glycoprotein (PSG); CEA gene family member (CGM);
D O I：
10.1006/scbi.1998.0119
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The human CEA family has been fully characterized, It comprizes 29 genes of which 18 are expressed; 7 belonging to the CEA subgroup and II to the pregnancy specific glycoprotein subgroup. CEA is an important tumor marker. for colorectal and some other carcinomas. The CEA subgroup members are cell membrane associated and show a complex expression pattern in normal and cancerous tissues with notably CEA showing a selective epithelial expression. Several CEA subgroup members possess cell adhesion properties and the primordial member, biliary glycoprotein, seems to function in signal transduction or regulation of signal transduction possibly in association with other CEA subfamily members. A modified ITAM/ITIM motif is identified in the cytoplasmatic domain of BGP. A role of CEA in innate immunity is envisioned.
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收藏
页码：67 / 81
页数：15
相关论文
共 108 条
[1]   CHARACTERIZATION OF A CDNA CLONE ENCODING A NEW SPECIES OF THE NONSPECIFIC CROSS-REACTING ANTIGEN (NCA), A MEMBER OF THE CEA GENE FAMILY [J].
ARAKAWA, F ;
KUROKI, M ;
MISUMI, Y ;
OIKAWA, S ;
NAKAZATO, H ;
MATSUOKA, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 166 (03) :1063-1071
[2]  
BARANOV V, 1994, CANCER RES, V54, P3305
[3]   CARCINOEMBRYONIC ANTIGENS - ALTERNATIVE SPLICING ACCOUNTS FOR THE MULTIPLE MESSENGER-RNAS THAT CODE FOR NOVEL MEMBERS OF THE CARCINOEMBRYONIC ANTIGEN FAMILY [J].
BARNETT, TR ;
KRETSCHMER, A ;
AUSTEN, DA ;
GOEBEL, SJ ;
HART, JT ;
ELTING, JJ ;
KAMARCK, ME .
JOURNAL OF CELL BIOLOGY, 1989, 108 (02) :267-276
[4]   ISOLATION AND CHARACTERIZATION OF FULL-LENGTH FUNCTIONAL CDNA CLONES FOR HUMAN CARCINOEMBRYONIC ANTIGEN [J].
BEAUCHEMIN, N ;
BENCHIMOL, S ;
COURNOYER, D ;
FUKS, A ;
STANNERS, CP .
MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (09) :3221-3230
[5]   Association of biliary glycoprotein with protein tyrosine phosphatase SHP-1 in malignant colon epithelial cells [J].
Beauchemin, N ;
Kunath, T ;
Robitaille, J ;
Chow, B ;
Turbide, C ;
Daniels, E ;
Veillette, A .
ONCOGENE, 1997, 14 (07) :783-790
[6]  
Behr TM, 1997, J NUCL MED, V38, P858
[7]  
Behr TM, 1996, CANCER RES, V56, P1805
[8]   CARCINOEMBRYONIC ANTIGEN, A HUMAN-TUMOR MARKER, FUNCTIONS AS AN INTERCELLULAR-ADHESION MOLECULE [J].
BENCHIMOL, S ;
FUKS, A ;
JOTHY, S ;
BEAUCHEMIN, N ;
SHIROTA, K ;
STANNERS, CP .
CELL, 1989, 57 (02) :327-334
[9]  
BERLING B, 1990, CANCER RES, V50, P6534
[10]   Extended glycoprotein structure of the seven domains in human carcinoembryonic antigen by X-ray and neutron solution scattering and an automated curve fitting procedure: Implications for cellular adhesion [J].
Boehm, MK ;
Mayans, MO ;
Thornton, JD ;
Begent, RHJ ;
Keep, PA ;
Perkins, SJ .
JOURNAL OF MOLECULAR BIOLOGY, 1996, 259 (04) :718-736
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