Bavachinin mitigates DMH induced colon cancer in rats by altering p53/Bcl2/BAX signaling associated with apoptosis

被引：18
|
作者：
Zhao, Chun [1 ]
Ghosh, Balaram [2 ]
Chakraborty, Tania [3 ]
Roy, Souvik [3 ]
机构：
[1] Xinghu Hosp, Dept Gen Surg, Suzhou Ind Pk, Suzhou, Peoples R China
[2] Midnapore Med Coll, Dept Pharmacol, Burdwan Pachim, India
[3] NSHM Knowledge Campus, Dept Pharmaceut Technol, Kolkata 700053, India
来源：
BIOTECHNIC & HISTOCHEMISTRY | 2021年 / 96卷 / 03期
关键词：
Apoptosis; bavachinin; cancer; colon; dimethylhydrazine; flavanone; Fructus Psoraleae; p53; Bcl2; BAX signaling; rats; ABERRANT CRYPT FOCI; PROLIFERATION; INHIBITION; EXPRESSION; FLAVONOIDS; PATHWAY; P53;
D O I：
10.1080/10520295.2020.1778087
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Bavachinin is a flavanone obtained from the Chinese herb,Fructus Psoraleae. Flavonoids and flavanones are recognized as cancer preventive agents. We investigated the anticancer properties of bavachinin using a model of dimethylhydrazine (DMH and dextran sodium sulfate (DSS) induced rat colon cancer. We investigated aberrant crypt foci (ACF), hyperplastic lesions, catalase (CAT), superoxide dismutase (SOD) and glutathione (GST) levels in Wistar rats. Expression of cancer biomarkers including IL-6, p53, Bcl2 and BAX was investigated. We found that bavachinin administered to rats re-established the colonic crypts that were damaged by DMH and prevented progression of the cancer.
引用
收藏
页码：179 / 190
页数：12
相关论文
共 50 条
  • [31] Raptinal ameliorates 1,2-dimethylhydrazine-induced colon cancer through p53/Bcl2/Bax/caspase-3-mediated apoptotic events in vitro and in vivo
    Lan, Yongting
    Yang, Yang
    Das, Abhijit
    Bhattacharya, Barshana
    Roy, Souvik
    INDIAN JOURNAL OF PHARMACOLOGY, 2023, 55 (02) : 97 - 107
  • [32] Apoptosis-related factors p53, Bcl(2), and Bax in neuroendocrine lung tumors
    Brambilla, E
    Negoescu, A
    Gazzeri, S
    Lantuejoul, S
    Moro, D
    Brambilla, C
    Coll, JL
    AMERICAN JOURNAL OF PATHOLOGY, 1996, 149 (06): : 1941 - 1952
  • [33] Effects of Bcl-2, bax and p53 Gene Protein Expressions in Gastric Cancer Tissue on the Apoptosis of Cancer Cells
    Zhang, Lei
    Li, Dapeng
    Lu, Guannan
    APPLIED MATERIALS AND TECHNOLOGIES FOR MODERN MANUFACTURING, PTS 1-4, 2013, 423-426 : 358 - +
  • [34] The role of p53, bcl-2 and bax network in dexamethasone induced apoptosis in multiple myeloma cell lines
    Tian, EM
    Gazitt, Y
    INTERNATIONAL JOURNAL OF ONCOLOGY, 1996, 8 (04) : 719 - 726
  • [35] Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio
    Chresta, CM
    Masters, JRW
    Hickman, JA
    CANCER RESEARCH, 1996, 56 (08) : 1834 - 1841
  • [36] The effect of Cressa Cretica hydroalcoholic extract on apoptosis and the expression of Bcl2, Bax and P53 genes in hepatoma cell line HepG2
    Pouraminaei, Mehdi
    Mirzaiey, Mohammad Reza
    Khoshdel, Alireza
    Hajizadeh, Mohammad Reza
    Mahmoodi, Mehdi
    Fahmidehkar, Mohammad Ali
    GENE REPORTS, 2020, 20
  • [37] Apoptofic markers p53, Bcl-2 and bax in primary lung cancer
    Porebska, Irena
    Wyrodek, Ewa
    Kosacka, Monika
    Adamiak, Jaroslaw
    Jankowska, Renata
    Harelozinska-Szmyrka, Antonina
    IN VIVO, 2006, 20 (05): : 599 - 604
  • [38] A Novel Peptide Derived from Ginger Induces Apoptosis through the Modulation of p53, BAX, and BCL2 Expression in Leukemic Cell Lines
    Chatupheeraphat, Chawalit
    Roytrakul, Sittiruk
    Phaonakrop, Narumon
    Deesrisak, Kamolchanok
    Krobthong, Sucheewin
    Anurathapan, Usanarat
    Tanyong, Dalina
    PLANTA MEDICA, 2021, 87 (07) : 560 - 569
  • [39] Phenylbutyrate-induced apoptosis and differential expression of Bcl-2, Bax, p53 and Fas in human prostate cancer cell lines
    Ng, AY
    Bales, W
    Veltri, RW
    ANALYTICAL AND QUANTITATIVE CYTOLOGY AND HISTOLOGY, 2000, 22 (01): : 45 - 54
  • [40] Drug-induced apoptosis and p53, BCL-2 and BAX expression in breast cancer tissues in vivo and in fibroblast cells in vitro
    Suzuki, K
    Kazui, T
    Yoshida, M
    Uno, T
    Kobayashi, T
    Kimura, T
    Yoshida, T
    Sugimura, H
    JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 1999, 29 (07) : 323 - 331
12345