Bavachinin mitigates DMH induced colon cancer in rats by altering p53/Bcl2/BAX signaling associated with apoptosis

被引：18
|
作者：
Zhao, Chun [1 ]
Ghosh, Balaram [2 ]
Chakraborty, Tania [3 ]
Roy, Souvik [3 ]
机构：
[1] Xinghu Hosp, Dept Gen Surg, Suzhou Ind Pk, Suzhou, Peoples R China
[2] Midnapore Med Coll, Dept Pharmacol, Burdwan Pachim, India
[3] NSHM Knowledge Campus, Dept Pharmaceut Technol, Kolkata 700053, India
来源：
BIOTECHNIC & HISTOCHEMISTRY | 2021年 / 96卷 / 03期
关键词：
Apoptosis; bavachinin; cancer; colon; dimethylhydrazine; flavanone; Fructus Psoraleae; p53; Bcl2; BAX signaling; rats; ABERRANT CRYPT FOCI; PROLIFERATION; INHIBITION; EXPRESSION; FLAVONOIDS; PATHWAY; P53;
D O I：
10.1080/10520295.2020.1778087
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Bavachinin is a flavanone obtained from the Chinese herb,Fructus Psoraleae. Flavonoids and flavanones are recognized as cancer preventive agents. We investigated the anticancer properties of bavachinin using a model of dimethylhydrazine (DMH and dextran sodium sulfate (DSS) induced rat colon cancer. We investigated aberrant crypt foci (ACF), hyperplastic lesions, catalase (CAT), superoxide dismutase (SOD) and glutathione (GST) levels in Wistar rats. Expression of cancer biomarkers including IL-6, p53, Bcl2 and BAX was investigated. We found that bavachinin administered to rats re-established the colonic crypts that were damaged by DMH and prevented progression of the cancer.
引用
收藏
页码：179 / 190
页数：12
相关论文
共 50 条
  • [1] Amelioration of DMH-induced colon cancer by eupafolin through the reprogramming of apoptosis-associated p53/Bcl2/Bax signaling in rats
    Wang, Congcong
    Qiao, Xiao
    Wang, Jingwen
    Yang, Jia
    Yang, Chen
    Qiao, Yi
    Guan, Yue
    Wen, Aidong
    Jiang, Liuqin
    EUROPEAN JOURNAL OF INFLAMMATION, 2022, 20
  • [2] Effects of karanjin on dimethylhydrazine induced colon carcinoma and aberrant crypt foci are facilitated by alteration of the p53/Bcl2/BAX pathway for apoptosis
    Zhang, Jingyu
    Xie, Yandong
    Fan, Qingling
    Wang, Cheng
    BIOTECHNIC & HISTOCHEMISTRY, 2021, 96 (03) : 202 - 212
  • [3] bcl2, p53 and bax in thyroid tumors and their relation to apoptosis
    Farid, P
    Gomba, S
    Péter, I
    Szende, B
    NEOPLASMA, 2001, 48 (04) : 299 - 301
  • [4] Borax-induced apoptosis in HepG2 cells involves p53, Bcl-2, and Bax
    Wei, Y.
    Yuan, F. J.
    Zhou, W. B.
    Wu, L.
    Chen, L.
    Wang, J. J.
    Zhang, Y. S.
    GENETICS AND MOLECULAR RESEARCH, 2016, 15 (02)
  • [5] The role of p53, bax, bcl2, and 8-OHdG in human acute myocardial infarction
    Najar, Reza Akbarzadeh
    Ghaderian, Sayyed Mohammad Hossein
    Vakili, Hosain
    Panah, Akram Sadat Tabatabaei
    Farimani, Azam Rezaei
    Rezaie, Gashin
    Harchegani, Asghar Beigi
    CENTRAL EUROPEAN JOURNAL OF BIOLOGY, 2010, 5 (04): : 439 - 445
  • [6] Analysis of p53 and BAX mutations, loss of heterozygosity, p53 and BCL2 expression and apoptosis in basal cell carcinoma in Korean patients
    Cho, S
    Hahm, JH
    Hong, YS
    BRITISH JOURNAL OF DERMATOLOGY, 2001, 144 (04) : 841 - 848
  • [7] The effect of Cressa Cretica hydroalcoholic extract on apoptosis and the expression of Bcl2, Bax and P53 genes in hepatoma cell line HepG2
    Pouraminaei, Mehdi
    Mirzaiey, Mohammad Reza
    Khoshdel, Alireza
    Hajizadeh, Mohammad Reza
    Mahmoodi, Mehdi
    Fahmidehkar, Mohammad Ali
    GENE REPORTS, 2020, 20
  • [8] Induction of apoptosis by p53, bax, bcl-2, and p21 expressed in colorectal cancer
    Kenji Katsumata
    Tetsuo Sumi
    Hidenori Tomioka
    Tatsuya Aoki
    Yasuhisa Koyanagi
    International Journal of Clinical Oncology, 2003, 8 (6) : 352 - 356
  • [9] TTDA inhibited apoptosis by regulating the p53-Bax/Bcl2 axis in glioma
    Bai, Huan-Lan
    Kang, Chun-Min
    Sun, Zhen-Qing
    Li, Xue-Heng
    Dai, Xiao-Yan
    Huang, Rui-Ying
    Zhao, Jing-Jing
    Bei, Yan-Rou
    Huang, Xian-Zhang
    Lu, Zhi-Feng
    Wu, Shao-Guo
    Lu, Jing-Bo
    Ping, Bao-Hong
    Wang, Qian
    Hu, Yan-Wei
    EXPERIMENTAL NEUROLOGY, 2020, 331
  • [10] Interleukin 7 signaling prevents apoptosis by regulating bcl-2 and bax via the p53 pathway in human non-small cell lung cancer cells
    Liu, Zi-Hui
    Wang, Ming-Hui
    Ren, Hong-Jiu
    Qu, Wei
    Sun, Li-Mei
    Zhang, Qing-Fu
    Qiu, Xue-Shan
    Wang, En-Hua
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2014, 7 (03): : 870 - 881
12345