Bavachinin mitigates DMH induced colon cancer in rats by altering p53/Bcl2/BAX signaling associated with apoptosis

被引：17

作者：

Zhao, Chun ^{[1
]}

Ghosh, Balaram ^{[2
]}

Chakraborty, Tania ^{[3
]}

Roy, Souvik ^{[3
]}

机构：

[1] Xinghu Hosp, Dept Gen Surg, Suzhou Ind Pk, Suzhou, Peoples R China

[2] Midnapore Med Coll, Dept Pharmacol, Burdwan Pachim, India

[3] NSHM Knowledge Campus, Dept Pharmaceut Technol, Kolkata 700053, India

来源：

BIOTECHNIC & HISTOCHEMISTRY | 2021年 / 96卷 / 03期

关键词：

Apoptosis; bavachinin; cancer; colon; dimethylhydrazine; flavanone; Fructus Psoraleae; p53; Bcl2; BAX signaling; rats; ABERRANT CRYPT FOCI; PROLIFERATION; INHIBITION; EXPRESSION; FLAVONOIDS; PATHWAY; P53;

D O I：

10.1080/10520295.2020.1778087

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Bavachinin is a flavanone obtained from the Chinese herb,Fructus Psoraleae. Flavonoids and flavanones are recognized as cancer preventive agents. We investigated the anticancer properties of bavachinin using a model of dimethylhydrazine (DMH and dextran sodium sulfate (DSS) induced rat colon cancer. We investigated aberrant crypt foci (ACF), hyperplastic lesions, catalase (CAT), superoxide dismutase (SOD) and glutathione (GST) levels in Wistar rats. Expression of cancer biomarkers including IL-6, p53, Bcl2 and BAX was investigated. We found that bavachinin administered to rats re-established the colonic crypts that were damaged by DMH and prevented progression of the cancer.

引用

页码：179 / 190

页数：12

共 50 条

[1] Amelioration of DMH-induced colon cancer by eupafolin through the reprogramming of apoptosis-associated p53/Bcl2/Bax signaling in rats
Wang, Congcong
Qiao, Xiao
Wang, Jingwen
Yang, Jia
Yang, Chen
Qiao, Yi
Guan, Yue
Wen, Aidong
Jiang, Liuqin
EUROPEAN JOURNAL OF INFLAMMATION, 2022, 20
[2] Amelioration of DMH-induced colon cancer by eupafolin through the reprogramming of apoptosis-associated p53/Bcl2/Bax signaling in rats
Wang, Congcong
Qiao, Xiao
Wang, Jingwen
Yang, Jia
Yang, Chen
Qiao, Yi
Guan, Yue
Wen, Aidong
Jiang, Liuqin
EUROPEAN JOURNAL OF INFLAMMATION, 2022, 20
[3] bcl2, p53 and bax in thyroid tumors and their relation to apoptosis
Farid, P
Gomba, S
Péter, I
Szende, B
NEOPLASMA, 2001, 48 (04) : 299 - 301
[4] RBBP6 gene in lung cancer: Correlation with apoptosis, Bax, Bcl2 and p53
Motadi, Lesetja
CANCER RESEARCH, 2009, 69
[5] Effects of karanjin on dimethylhydrazine induced colon carcinoma and aberrant crypt foci are facilitated by alteration of the p53/Bcl2/BAX pathway for apoptosis
Zhang, Jingyu
Xie, Yandong
Fan, Qingling
Wang, Cheng
BIOTECHNIC & HISTOCHEMISTRY, 2021, 96 (03) : 202 - 212
[6] Analysis of p53 and BAX mutations, loss of heterozygosity, p53 and BCL2 expression and apoptosis in basal cell carcinoma in Korean patients
Cho, S
Hahm, JH
Hong, YS
BRITISH JOURNAL OF DERMATOLOGY, 2001, 144 (04) : 841 - 848
[7] Effects of p53 and Bcl-2/Bax on apoptosis of thymocytes induced by ionizing radiation
Fushe Yanjiu yu Fushe Gongyi Xuebao, 2 (119-122):
[8] A novel EGFR inhibitor, HNPMI, regulates apoptosis and oncogenesis by modulating BCL-2/BAX and p53 in colon cancer
Kandhavelu, Jeyalakshmi
Subramanian, Kumar
Naidoo, Vivash
Sebastianelli, Giulia
Doan, Phuong
Mani, Saravanan Konda
Yapislar, Hande
Haciosmanoglu, Ebru
Arslan, Leman
Ozer, Samed
Thiyagarajan, Ramesh
Candeias, Nuno R.
Penny, Clement
Kandhavelu, Meenakshisundaram
Murugesan, Akshaya
BRITISH JOURNAL OF PHARMACOLOGY, 2024, 181 (01) : 107 - 124
[9] Umbelliprenin-loaded nanostructured lipid carrier: A novel approach for inducing cytotoxicity and apoptosis in colorectal cancer cells by altering the p53, survivin, and Bax/Bcl2 ratio
Kamalkazemi, Elham
Dehghan, Gholamreza
Abedi-Gaballu, Fereydoon
Babaei, Esmaeil
Baradaran, Behzad
GENE REPORTS, 2023, 30
[10] Abnormalities of the P53, MDM2, BCL2 and BAX genes in acute leukemias
Wojcik, I
Szybka, M
Golanska, E
Rieske, P
Blonski, JZ
Robak, T
Bartkowiak, J
NEOPLASMA, 2005, 52 (04) : 318 - 324

← 1 2 3 4 5 →