Photo-Crosslinked Biodegradable Hydrogels Prepared From Fumaric Acid Monoethyl Ester-Functionalized Oligomers for Protein Delivery

被引：15

作者：

Jansen, Janine ^{[1
]}

Mihov, George ^{[4
]}

Feijen, Jan ^{[3
]}

Grijpma, Dirk W. ^{[1
,2
]}

机构：

[1] Univ Twente, MIRA Inst Biomed Technol & Tech Med, Dept Biomat Sci & Technol, Fac Sci & Technol, NL-7500 AE Enschede, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Engn, WJ Kolff Inst, NL-9713 AV Groningen, Netherlands

[3] Univ Twente, MIRA Inst Biomed Technol & Tech Med, Dept Polymer Chem & Biomat, Fac Sci & Technol, NL-7500 AE Enschede, Netherlands

[4] DSM Ahead, NL-6160 MD Geleen, Netherlands

来源：

MACROMOLECULAR BIOSCIENCE | 2012年 / 12卷 / 05期

关键词：

drug delivery systems; hydrogels; networks; photopolymerization; proteins; IN-VITRO DEGRADATION; TRIMETHYLENE CARBONATE; EPSILON-CAPROLACTONE; CONTROLLED-RELEASE; 1,3-TRIMETHYLENE CARBONATE; MECHANICAL-PROPERTIES; BLOCK-COPOLYMERS; LINKING; BEHAVIOR; VIVO;

D O I：

10.1002/mabi.201100468

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Photo-crosslinkable, fumaric acid monoethyl ester-functionalized triblock oligomers are synthesized and copolymerized with N-vinyl-2-pyrrolidone to form biodegradable photo-crosslinked hydrogels. Poly(ethylene glycol) is used as the middle hydrophilic segment and the hydrophobic segments are based on D,L-lactide, trimethylene carbonate or a mixture of these monomers. Two model proteins, lysozyme and albumin, are incorporated in the hydrogels and their release is studied. The composition of the hydrophobic segments could be used to tune degradation behavior and release rates. Careful optimization of photo-polymerization conditions is needed to limit conjugation of proteins to the hydrogels and protein denaturation.

引用

页码：692 / 702

页数：11

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