Risk of cardiovascular events in men treated for prostate cancer compared with prostate cancer-free men

被引:12
作者
Moustsen, Ida Rask [1 ]
Larsen, Signe Benzon [1 ,2 ]
Duun-Henriksen, Anne Katrine [3 ]
Tjonneland, Anne [4 ,5 ]
Kjaer, Susanne K. [6 ]
Brasso, Klaus [2 ]
Johansen, Christoffer [1 ,7 ]
Dalton, Susanne Oksbjerg [1 ,8 ]
机构
[1] Danish Canc Soc Res Ctr, Survivorship, Copenhagen, Denmark
[2] Copenhagen Univ Hosp, Rigshosp, Dept Urol, Copenhagen Prostate Canc Ctr, Copenhagen, Denmark
[3] Danish Canc Soc Res Ctr, Stat & Pharmacoepidemiol, Copenhagen, Denmark
[4] Danish Canc Soc Res Ctr, Diet Genes & Environm, Copenhagen, Denmark
[5] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark
[6] Danish Canc Soc Res Ctr, Virus Lifestyle & Genes, Copenhagen, Denmark
[7] Univ Copenhagen, Finsen Ctr, Rigshosp 5073, Oncol Clin, DK-2100 Copenhagen, Denmark
[8] Zealand Univ Hosp Naestved, Dept Oncol, Naestved, Denmark
关键词
ANDROGEN-DEPRIVATION THERAPY; METABOLIC SYNDROME; BODY-COMPOSITION; DISEASE; STROKE; PARTICIPATION; MORTALITY; REGISTER; COHORT; DIET;
D O I
10.1038/s41416-019-0468-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND: The effect of lifestyle, anthropometry and cardiovascular risk factors on cardiovascular disease in men with prostate cancer (PCa) remains unclear. METHODS: Using a population-based cohort of 25,436 Danish, cancer-free men aged 50-64 years, we obtained information on selfreported pre-cancer lifestyle, objectively measured anthropometry and cardiovascular risk factors, and linked them to national health registers for information on major cardiovascular outcomes. We assessed hazard ratios (HRs) of incident acute myocardial infarction (MI), ischaemic stroke (IS) and heart failure (HF) among 1546 men diagnosed with PCa treated with first-line active surveillance, watchful waiting, intended curative or palliative treatment compared with PCa-free men during 18 years of follow-up. RESULTS: Men who received first-line palliative treatment had higher rates of IS and HF with adjusted HRs of 2.09 (95% CI 1.49-2.93) and 2.05 (95% CI 1.43-2.94), respectively, compared with PCa-free men. The risks were increased from start of treatment. We did not find the same relation for men in any other treatment group. No differences between men treated for PCa and cancerfree controls were observed for MI after adjustment for lifestyle, anthropometry, and cardiovascular risk factors. CONCLUSION: Pre-diagnosis lifestyle, anthropometry or cardiovascular risk factors did not explain the risk of IS and HF in PCa patients receiving palliative treatment. The results emphasise the need for balancing disease management and monitoring of cardiovascular health in this patient group.
引用
收藏
页码:1067 / 1074
页数:8
相关论文
共 41 条
[1]   Cardiovascular Disease Among Survivors of Adult-Onset Cancer: A Community-Based Retrospective Cohort Study [J].
Armenian, Saro H. ;
Xu, Lanfang ;
Ky, Bonnie ;
Sun, Canlan ;
Farol, Leonardo T. ;
Pal, Sumanta Kumar ;
Douglas, Pamela S. ;
Bhatia, Smita ;
Chao, Chun .
JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (10) :1122-+
[2]   Androgen-Deprivation Therapy and the Risk of Stroke in Patients With Prostate Cancer [J].
Azoulay, Laurent ;
Yin, Hui ;
Benayoun, Serge ;
Renoux, Christel ;
Boivin, Jean-Francois ;
Suissa, Samy .
EUROPEAN UROLOGY, 2011, 60 (06) :1244-1250
[3]   Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapy [J].
Basaria, S ;
Muller, DC ;
Carducci, MA ;
Egan, J ;
Dobs, AS .
CANCER, 2006, 106 (03) :581-588
[4]   International Variation in Prostate Cancer Incidence and Mortality Rates [J].
Center, Melissa M. ;
Jemal, Ahmedin ;
Lortet-Tieulent, Joannie ;
Ward, Elizabeth ;
Ferlay, Jacques ;
Brawley, Otis ;
Bray, Freddie .
EUROPEAN UROLOGY, 2012, 61 (06) :1079-1092
[5]   The cardiovascular risk of gonadotropin releasing hormone agonists in men with prostate cancer: An unresolved controversy [J].
Conteduca, Vincenza ;
Di Lorenzo, Giuseppe ;
Tartarone, Alfredo ;
Aieta, Michele .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2013, 86 (01) :42-51
[6]   The metabolic syndrome in cancer survivors [J].
de Haas, Esther C. ;
Oosting, Sjoukje F. ;
Lefrandt, Joop D. ;
Wolffenbuttel, Bruce H. R. ;
Sleijfer, Dirk Th ;
Gietema, Jourik A. .
LANCET ONCOLOGY, 2010, 11 (02) :193-203
[7]   Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies [J].
de Koning, Lawrence ;
Merchant, Anwar T. ;
Pogue, Janice ;
Anand, Sonia S. .
EUROPEAN HEART JOURNAL, 2007, 28 (07) :850-856
[8]  
Engholm G., 2016, NORDCAN: Cancer Incidence, Mortality
[9]   Effect of metabolic syndrome and its components on prostate cancer risk: Meta-analysis [J].
Esposito, K. ;
Chiodini, P. ;
Capuano, A. ;
Bellastella, G. ;
Maiorino, M. I. ;
Parretta, E. ;
Lenzi, A. ;
Giugliano, D. .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2013, 36 (02) :132-139
[10]   Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer [J].
Fizazi, Karim ;
NamPhuong Tran ;
Fein, Luis ;
Matsubara, Nobuaki ;
Rodriguez-Antolin, Alfredo ;
Alekseev, Boris Y. ;
Ozguroglu, Mustafa ;
Ye, Dingwei ;
Feyerabend, Susan ;
Protheroe, Andrew ;
De Porre, Peter ;
Kheoh, Thian ;
Park, Youn C. ;
Todd, Mary B. ;
Chi, Kim N. .
NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (04) :352-360