A new gliotoxin analogue from a marine-derived fungus Aspergillus fumigatus Fres

被引：29

作者：

Zhao, Wen Ying ^{[1
,2
]}

Zhu, Tian Jiao ^{[1
]}

Han, Xiao Xian ^{[1
]}

Fan, Guo Tao ^{[1
]}

Liu, Hong Bing ^{[1
]}

Zhu, Wei Ming ^{[1
]}

Gu, Qian Qun ^{[1
]}

机构：

[1] Ocean Univ China, Key Lab Marine Drugs, Minist Educ, Marine Drugs & Food Inst, Qingdao, Peoples R China

[2] Univ Sci & Technol, Coll Chem Engn, Qingdao, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2009年 / 23卷 / 03期

关键词：

marine-derived fungus; Aspergillus fumigatus; gliotoxin analogues; cytotoxic activity; DERIVATIVES;

D O I：

10.1080/14786410600906970

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new gliotoxin analogue (1), as well as four known compounds gliotoxin (2), bisdethiobis (methylthio) gliotoxin (3), bis-N-norgliovictin (4) and didehydrobisdethiobis (methylthio) gliotoxin (5), were isolated from a culture of marine-derived fungus Aspergillus fumigatus Fres. The structure of 1 was determined on the basis of spectroscopic methods. All five compounds were evaluated for the cytotoxic effects on tsFT210 cell line by the SRB method.

引用

页码：203 / 207

页数：5

共 13 条

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BOENTE MIP, 1991, J CHEM SOC PERK T, V1, P1283

[2] Novel cytotoxic thiodiketopiperazine derivatives from a Tilachlidium sp. [J].