Platelet function in hypertension

被引：64
作者：
El Haouari, Mohammed [1 ]
Rosado, Juan A. [2 ]
机构：
[1] Univ Mohammed 1, Dept Biol, Lab Physiol & Ethnopharmacol, Fac Sci, Oujda 60000, Morocco
[2] Univ Extremadura, Cell Physiol Res Grp, Dept Physiol, Caceres 10071, Spain
来源：
BLOOD CELLS MOLECULES AND DISEASES | 2009年 / 42卷 / 01期
关键词：
Platelets; Hypertension; Ca2+ signaling; Reactive oxygen species; Nitric oxide; ENDOTHELIAL GROWTH-FACTOR; MEDIATED CALCIUM-ENTRY; CORONARY-ARTERY-DISEASE; NITRIC-OXIDE SYNTHASE; VASODILATOR-STIMULATED PHOSPHOPROTEIN; DEPENDENT VASCULAR RELAXATION; PLASMA-MEMBRANE CA2+-ATPASE; SOLUBLE P-SELECTIN; CYCLIC-NUCLEOTIDES; HYDROGEN-PEROXIDE;
D O I：
10.1016/j.bcmd.2008.07.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Platelets from hypertensive patients show increased sensitivity to agonists and have high intracellular free Ca2+ concentration. Furthermore, in hypertension, platelets show enhanced endogenous production of reactive oxygen species and a reduced antioxidant status which increases protein tyrosine phosphorylation, enhances Ca2+ mobilization and attenuates NO bioavailability. The study of the abnormalities in platelet function in hypertensive patients can lead to the development of new pharmacological strategies to prevent and/or palliate hypertension-derived complications associated to platelet hyperactivity. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：38 / 43
页数：6
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