Platelet function in hypertension

被引：64

作者：

El Haouari, Mohammed ^{[1
]}

Rosado, Juan A. ^{[2
]}

机构：

[1] Univ Mohammed 1, Dept Biol, Lab Physiol & Ethnopharmacol, Fac Sci, Oujda 60000, Morocco

[2] Univ Extremadura, Cell Physiol Res Grp, Dept Physiol, Caceres 10071, Spain

来源：

BLOOD CELLS MOLECULES AND DISEASES | 2009年 / 42卷 / 01期

关键词：

Platelets; Hypertension; Ca2+ signaling; Reactive oxygen species; Nitric oxide; ENDOTHELIAL GROWTH-FACTOR; MEDIATED CALCIUM-ENTRY; CORONARY-ARTERY-DISEASE; NITRIC-OXIDE SYNTHASE; VASODILATOR-STIMULATED PHOSPHOPROTEIN; DEPENDENT VASCULAR RELAXATION; PLASMA-MEMBRANE CA2+-ATPASE; SOLUBLE P-SELECTIN; CYCLIC-NUCLEOTIDES; HYDROGEN-PEROXIDE;

D O I：

10.1016/j.bcmd.2008.07.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Platelets from hypertensive patients show increased sensitivity to agonists and have high intracellular free Ca2+ concentration. Furthermore, in hypertension, platelets show enhanced endogenous production of reactive oxygen species and a reduced antioxidant status which increases protein tyrosine phosphorylation, enhances Ca2+ mobilization and attenuates NO bioavailability. The study of the abnormalities in platelet function in hypertensive patients can lead to the development of new pharmacological strategies to prevent and/or palliate hypertension-derived complications associated to platelet hyperactivity. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：38 / 43

页数：6

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