Characteristics of anti-HCV antibody-positive patients with hepatocellular carcinoma on chronic hemodialysis: Recommendation of periodic ultrasonography for early detection

被引：7
作者：
Sakai, Y
Izumi, N
Tazawa, J
Uchihara, M
Akiba, T
Marumo, F
Sato, C
机构：
[1] TOKYO MED & DENT UNIV,FAC MED,DEPT INTERNAL MED 2,BUNKYO KU,TOKYO 113,JAPAN
[2] TOKYO MED & DENT UNIV,FAC MED,DIV HLTH SCI,TOKYO 113,JAPAN
[3] TSUCHIURA KYODO GEN HOSP,DEPT INTERNAL MED,TSUCHIURA,IBARAKI,JAPAN
[4] MUSASHINO RED CROSS HOSP,DEPT INTERNAL MED,MUSASHINO,TOKYO,JAPAN
来源：
NEPHRON | 1996年 / 74卷 / 02期
关键词：
hemodialysis; hepatitis C; hepatocellular carcinoma; liver cirrhosis; prognosis;
D O I：
10.1159/000189340
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
We analyzed 10 patients (male:female 9:1, mean age 64.2 years) who developed hepatocelluar carcinoma during the observation period of 2 years among 2,164 chronic hemodialysis patients in 23 dialysis centers. Among them, 409 patients were positive for serum anti-HCV antibodies (19%). They were all positive for serum anti-HCV antibodies but negative for HBs antigen. None of the anti-HCV antibody-negative patients developed hepatocellular carcinoma during this period. Although liver function tests of the patients were almost normal, pathological examination of the liver revealed chronic active hepatitis or cirrhosis. Periodic ultrasonographic examination is necessary for early detection of hepatocellular carcinoma in chronic hemodialysis patients with positive anti-HCV antibodies even if liver function tests are within normal ranges.
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收藏
页码：386 / 389
页数：4
相关论文
共 17 条
  • [11] NOZAKI H, 1993, JPN J SURG, V54, P160
  • [12] NOZAKI H, 1993, JPN J SURG, V54, P1607
  • [13] PREVALENCE OF HEPATITIS-C VIRUS-INFECTION AMONG LONG-TERM HEMODIALYSIS-PATIENTS - DETECTION OF HEPATITIS-C VIRUS-RNA IN PLASMA
    SAKAMOTO, N
    ENOMOTO, N
    MARUMO, F
    SATO, C
    [J]. JOURNAL OF MEDICAL VIROLOGY, 1993, 39 (01) : 11 - 15
  • [14] WALF PL, 1972, CLIN CHEM, V18, P567
  • [15] YAMAGATA M, 1993, HEPATO-GASTROENTEROL, V40, P249
  • [16] YAZAKI K, 1994, J JPN SOC DIAL THER, V27, P1445
  • [17] THE PREVALENCE OF HEPATITIS-C VIRUS-ANTIBODIES AMONG HEMODIALYSIS-PATIENTS
    ZELDIS, JB
    DEPNER, TA
    KURAMOTO, IK
    GISH, RG
    HOLLAND, PV
    [J]. ANNALS OF INTERNAL MEDICINE, 1990, 112 (12) : 958 - 960
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