Epigenetics of Progression of Chronic Kidney Disease: Fact or Fantasy?

被引：63
作者：
Wing, Maria R. [1 ]
Ramezani, Ali [1 ]
Gill, Harindarpal S. [1 ]
Devaney, Joseph M. [2 ]
Raj, Dominic S. [1 ]
机构：
[1] George Washington Univ, Div Renal Dis & Hypertens, Washington, DC 20037 USA
[2] Childrens Natl Med Ctr, Med Genet Res Ctr, Washington, DC 20010 USA
来源：
SEMINARS IN NEPHROLOGY | 2013年 / 33卷 / 04期
基金：
美国国家卫生研究院;
关键词：
DNA methylation; microRNAs; chronic kidney disease (CKD); EMT; renal fibrosis; NF-KAPPA-B; STAGE RENAL-DISEASE; DNA METHYLATION; PROMOTER METHYLATION; COMPLEX DISEASE; ANGIOTENSIN-II; EXPRESSION; MICRORNAS; FIBROSIS; ASSOCIATION;
D O I：
10.1016/j.semnephrol.2013.05.008
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Epigenetic modifications are important in the normal functioning of the cell, from regulating dynamic expression of essential genes and associated proteins to repressing those that are unneeded. Epigenetic changes are essential for development and functioning of the kidney, and aberrant methylation, histone modifications, and expression of microRNA could lead to chronic kidney disease (CKD). Here, epigenetic modifications modulate transforming growth factor p signaling, inflammation, profibrotic genes, and the epithelial-to-mesenchymal transition, promoting renal fibrosis and progression of CKD. Identification of these epigenetic changes is important because they are potentially reversible and may serve as therapeutic targets in the future to prevent subsequent renal fibrosis and CKD. In this review we discuss the different types of epigenetic control, methods to study epigenetic modifications, and how epigenetics promotes progression of CKD. (C) 2013 Elsevier Inc. All rights reserved.
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收藏
页码：363 / 374
页数：12
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