CDX-2, a new marker for adenocarcinoma of gastrointestinal origin

被引:57
作者
Li, MK
Folpe, AL
机构
[1] Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
[2] Univ Florida, Dept Pathol Immunol & Lab Med, Gainesville, FL USA
关键词
CDX-2; adenocarcinoma; immunohistochemistry; metastasis; intestinal metaplasia; dysplasia; adenoma;
D O I
10.1097/00125480-200403000-00004
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
CDX2-88 is a recently developed monoclonal antibody to the intestinal epithelia-specific nuclear transcription factor CDX2. CDX2 immunohistochemistry has recently been shown to be useful in establishing gastrointestinal origin in metastatic tumors and will likely become a useful addition to the standard panel of immunostains for carcinomas of unknown primary sites. This article reviews the previous studies of this new antibody.
引用
收藏
页码:101 / 105
页数:5
相关论文
共 26 条
  • [1] CDX-2 homeobox gene expression is a reliable marker of colorectal adenocarcinoma metastases to the lungs
    Barbareschi, M
    Murer, B
    Colby, TV
    Chilosi, M
    Macri, E
    Loda, M
    Doglioni, C
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2003, 27 (02) : 141 - 149
  • [2] Homeosis and intestinal tumours in Cdx2 mutant mice
    Chawengsaksophak, K
    James, R
    Hammond, VE
    Kontgen, F
    Beck, F
    [J]. NATURE, 1997, 386 (6620) : 84 - 87
  • [3] CDX2 is mutated in a colorectal cancer with normal APC/β-catenin signaling
    da Costa, LT
    He, TC
    Yu, J
    Sparks, AB
    Morin, PJ
    Polyak, K
    Laken, S
    Vogelstein, B
    Kinzler, KW
    [J]. ONCOGENE, 1999, 18 (35) : 5010 - 5014
  • [4] Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa
    Eda, A
    Osawa, H
    Satoh, K
    Yanaka, I
    Kihira, K
    Ishino, Y
    Mutoh, H
    Sugano, K
    [J]. JOURNAL OF GASTROENTEROLOGY, 2003, 38 (01) : 14 - 22
  • [5] The Cdx-1 and Cdx-2 homeobox genes in the intestine
    Freund, JN
    Domon-Dell, C
    Kedinger, M
    Duluc, I
    [J]. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 1998, 76 (06): : 957 - 969
  • [6] Furlanetto A, 2003, MODERN PATHOL, V16, p273A
  • [7] Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon
    Hinoi, T
    Tani, M
    Lucas, PC
    Caca, K
    Dunn, RL
    Macri, E
    Loda, M
    Appelman, HD
    Cho, KR
    Fearon, ER
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2001, 159 (06) : 2239 - 2248
  • [8] CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia
    Hinoi, T
    Lucas, PC
    Kuick, R
    Hanash, S
    Cho, KR
    Fearon, ER
    [J]. GASTROENTEROLOGY, 2002, 123 (05) : 1565 - 1577
  • [9] JAMES R, 1994, J BIOL CHEM, V269, P15229
  • [10] Jin TR, 1996, MOL CELL BIOL, V16, P19