Genetic polymorphism in IFNL4 and response to pegylated interferon-α and ribavirin in Japanese chronic hepatitis C patients

被引：11

作者：

Nozawa, Y. ^{[1
]}

Umemura, T. ^{[1
]}

Katsuyama, Y. ^{[2
]}

Shibata, S. ^{[1
]}

Kimura, T. ^{[1
]}

Morita, S. ^{[1
]}

Joshita, S. ^{[1
]}

Komatsu, M. ^{[1
]}

Matsumoto, A. ^{[1
]}

Yoshizawa, K. ^{[1
]}

Ota, M. ^{[3
]}

Tanaka, E. ^{[1
]}

机构：

[1] Shinshu Univ, Sch Med, Dept Med, Div Gastroenterol & Hepatol, Matsumoto, Nagano 3908621, Japan

[2] Shinshu Univ Hosp, Dept Pharm, Matsumoto, Nagano, Japan

[3] Shinshu Univ, Sch Med, Dept Legal Med, Matsumoto, Nagano 3908621, Japan

来源：

TISSUE ANTIGENS | 2014年 / 83卷 / 01期

关键词：

hepatitis C virus; interferon-lambda; 4; IL28B; pegylated interferon; NON-B-HEPATITIS; HEPATOCELLULAR-CARCINOMA; GENOTYPE; NON-A; VIRUS; IL28B; ASSOCIATION; CLEARANCE; TRANSFUSION; PREDICTION;

D O I：

10.1111/tan.12264

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A genetic polymorphism of the newly discovered interferon-lambda 4 (IFNL4) gene was associated with hepatitis C virus (HCV) clearance in individuals of African ancestry. To assess whether a dinucleotide variant of IFNL4 (ss469415590) also affected treatment outcome of antiviral therapy in Japan, we genotyped 213 patients with chronic genotype 1 HCV infection and 176 healthy subjects. The Delta G allele was associated with treatment failure [odds ratio (OR) 4.73, P = 0.019], as was the IFL3 rs80999:17 single nucleotide polymorphism (SNP) (OR 5.06, P=0.068). T h e correlation between ss469415590 and rs8099917 was high (r(2) = 0.92, D' = 0.98). Multivariate analysis revealed that the rs8099917 SNP was independently associated with treatment failure (OR 5.28, P = 0.009). Therefore, ss469415590 may be another predictive marker of antiviral therapy outcome in the Japanese population.

引用

页码：45 / 48

页数：4

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