Direct Acyl Radical Addition to 2H-Indazoles Using Ag-Catalyzed Decarboxylative Cross-Coupling of α-Keto Acids

被引：105

作者：

Bogonda, Ganganna ^{[1
]}

Kim, Hun Young ^{[1
]}

Oh, Kyungsoo ^{[1
]}

机构：

[1] Chung Ang Univ, Ctr Metareceptome Res, Coll Pharm, 84 Heukseok Ro, Seoul 06974, South Korea

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

N BOND FORMATION; INDAZOLE DERIVATIVES; OXOCARBOXYLIC ACIDS; SUBSTITUTED; 3-AMINOINDAZOLES; PHOTOREDOX CATALYSIS; EFFICIENT SYNTHESIS; CARBOXYLIC-ACIDS; ACYLATION; DESIGN; ARYNES;

D O I：

10.1021/acs.orglett.8b00920

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A direct acyl radical addition to 2H-indazoles has been achieved for the first time, where the less-aromatic quinonoid 2H-indazoles readily accepted radical species to the C-3 position. Motivated by the lack of direct acylation strategy for 2H-indazoles, the current method utilizes the radical acceptability of 2H-indazoles, discovering an ambient temperature reaction to provide facile access to a diverse array of 3-aryl-2H-indazoles with three points of structural diversification in 25%-83% yields.

引用

页码：2711 / 2715

页数：5

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