A common genetic variant is associated with adult and childhood obesity

被引：504
作者：
Herbert, A
Gerry, NP
McQueen, MB
Heid, IM
Pfeufer, A
Illig, T
Wichmann, HE
Meitinger, T
Hunter, D
Hu, FB
Colditz, G
Hinney, A
Hebebrand, J
Koberwitz, K
Zhu, XF
Cooper, R
Ardlie, K
Lyon, H
Hirschhorn, JN
Laird, NM
Lenburg, ME
Lange, C
Christman, MF
机构：
[1] Boston Univ, Sch Med, Dept Genet & Genom, Boston, MA 02118 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[3] Forschungszentrum Umwelt & Gesundheit, Inst Human Genet, D-85764 Neuherberg, Germany
[4] Tech Univ Munich, Inst Human Genet, D-81671 Munich, Germany
[5] Univ Munich, Inst Med Informat Biometry & Epidemiol, Munich, Germany
[6] Brigham & Womens Hosp, Nurses Hlth Study, Boston, MA 02115 USA
[7] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA
[8] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
[9] Univ Duisburg Essen, Dept Child & Adolescent Psychiat, D-45147 Essen, Germany
[10] Loyola Univ, Med Ctr, Dept Epidemiol & Prevent Med, Maywood, IL 60153 USA
[11] SeraCare Life Sci, Genom Collaborat, Cambridge, MA USA
[12] Childrens Hosp, Program Genom, Boston, MA 02115 USA
[13] Childrens Hosp, Div Genet, Boston, MA 02115 USA
[14] Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
[15] Harvard Univ, Broad Inst, Cambridge, MA 02139 USA
[16] MIT, Cambridge, MA 02139 USA
[17] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
来源：
SCIENCE | 2006年 / 312卷 / 5771期
关键词：
D O I：
10.1126/science.1124779
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.
引用
收藏
页码：279 / 283
页数：5
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