Cytochrome p450 Part 3: Drug Interactions Essential Concepts and Considerations

被引：7
作者：
Krau, Stephen D. [1 ]
机构：
[1] Vanderbilt Univ, Med Ctr, Sch Nursing, Nashville, TN 37240 USA
来源：
NURSING CLINICS OF NORTH AMERICA | 2013年 / 48卷 / 04期
关键词：
Cytochrome p450; Inducers; Inhibitors; Drug interactions; Cancer therapy; Grapefruit juice; Medication administration; GRAPEFRUIT JUICE; RHABDOMYOLYSIS;
D O I：
10.1016/j.cnur.2013.09.004
中图分类号：
R47 [护理学];
学科分类号：
1011 ;
摘要：
The most important considerations related to understanding cytochrome p450 enzymes is the appreciation that all drug effects vary among individuals and, although there are multiple causes of these variations, drug effects are strongly influenced by genes. Nurses who administer and monitor, or prescribe, these medications can only be safe if there is understanding of these processes. The same enzyme may display a variety of functions and alterations, which can range from ultrarapid activity to no activity. Foods given with medications also can affect the metabolism of the medication. Each cytochrome p450 subfamily is instrumental in the metabolism of numerous drugs.
引用
收藏
页码：697 / +
页数：11
相关论文
共 16 条
  • [1] Pharmacogenomics of adverse drug reactions: practical applications and perspectives
    Becquemont, Laurent
    [J]. PHARMACOGENOMICS, 2009, 10 (06) : 961 - 969
  • [2] Bojanic Zoran Z, 2010, Med Pregl, V63, P805
  • [3] Chang Thomas K. H., 2008, P480, DOI 10.1039/9781847558428-00480
  • [4] Updates on Cytochrome P450-Mediated Cardiovascular Drug Interactions
    Cheng, Judy W. M.
    Frishman, William H.
    Aronow, Wilbert S.
    [J]. AMERICAN JOURNAL OF THERAPEUTICS, 2009, 16 (02) : 155 - 163
  • [5] Drug interactions and anti-infective therapies
    Gregg, CR
    [J]. AMERICAN JOURNAL OF MEDICINE, 1999, 106 (02) : 227 - 237
  • [6] Guo LQ, 2000, DRUG METAB DISPOS, V28, P766
  • [7] Rhabdomyolysis induced by simvastatin-fluconazole combination
    Hazin, Ribhi
    Abuzetun, Jamil Y.
    Suker, Manar
    Porter, Joann
    [J]. JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION, 2008, 100 (04) : 444 - 446
  • [8] Medicinal importance of grapefruit juice and its interaction with various drugs
    Kiani, Jawad
    Imam, Sardar Z.
    [J]. NUTRITION JOURNAL, 2007, 6 (1)
  • [9] Implications for Educating the Next Generation of Nurses on Genetics and Genomics in the 21st Century
    Lea, Dale Halsey
    Skirton, Heather
    Read, Catherine Y.
    Williams, Janet K.
    [J]. JOURNAL OF NURSING SCHOLARSHIP, 2011, 43 (01) : 3 - 12
  • [10] Lynch T, 2007, AM FAM PHYSICIAN, V76, P391
12