Near-Infrared (NIR)-Absorbing Conjugated Polymer Dots as Highly Effective Photothermal Materials for In Vivo Cancer Therapy

被引：205
作者：
Li, Shengliang [1 ]
Wang, Xiaoyu [1 ]
Hu, Rong [1 ]
Chen, Hui [1 ]
Li, Meng [1 ]
Wang, Jianwu [1 ]
Wang, Yunxia [1 ]
Liu, Libing [1 ]
Lv, Fengting [1 ]
Liang, Xing-Jie [2 ]
Wang, Shu [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
[2] Chinese Acad Sci, Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Ctr Excellence Nanosci, Beijing 100190, Peoples R China
来源：
CHEMISTRY OF MATERIALS | 2016年 / 28卷 / 23期
关键词：
CONVERSION EFFICIENCY; ENERGY-TRANSFER; NANOPARTICLES; CELLS; FLUORESCENCE; OXYGEN; MORPHOLOGY; NANOPROBE; ABLATION; AGENT;
D O I：
10.1021/acs.chemmater.6b03738
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Photothermal therapy (PTT) holds great promise for noninvasive cancer treatment. To fulfill this goal, highly effective and low-risk photothermal agents have been intensively explored. Here, we present a new PTT material based on conjugated polymer dots (Pdots) that exhibit strong near-infrared (NIR) absorption and high photostability. The Pdots result in a thermal response upon illumination with a NIR laser, leading to a high photothermal conversion efficiency of 65%. Thus, the photothermal ablation of cancer cells using the Pdots both in vitro and in vivo can be achieved, highlighting the potential of Pdots as a nanoplatform for clinical therapy. They also open up a new avenue to develop new photothermal therapeutic materials.
引用
收藏
页码：8669 / 8675
页数：7
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