Neurodevelopmental outcome at 2 years of age in preterm infants with late-onset sepsis

被引:26
作者
Zonnenberg, I. A. [1 ]
van Dijk-Lokkart, E. M. [2 ]
van den Dungen, F. A. M. [1 ]
Vermeulen, R. J. [3 ,4 ]
van Weissenbruch, M. M. [1 ]
机构
[1] Vrije Univ Amsterdam, Dept Neonatol, Emma Childrens Hosp Amsterdam UMC, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, Dept Med Psychol, Amsterdam UMC, Amsterdam, Netherlands
[3] Vrije Univ Amsterdam, Dept Child Neurol, Emma Childrens Hosp, Amsterdam UMC,Neurosci Campus Amsterdam, Amsterdam, Netherlands
[4] MUMC, Child Neurol, Dept Neurolo, Maastricht, Netherlands
关键词
Late-onset sepsis; Neurodevelopmental outcome; Preterm infant; NEONATAL INFECTION;
D O I
10.1007/s00431-019-03339-2
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Late-onset sepsis is associated with impaired neurodevelopmental outcome in preterm infants. This prospective cohort study aims to establish the effect of sepsis after 72 h of life on cognitive, psychomotor, and language development of preterm infants (below 32 weeks gestational age and/or below 1500 g). At 2 years corrected age, neurodevelopmental outcome was tested using Bayley's Scales of Infant Development-II, Lexilijst (lexical development questionnaire), and behavior checklists. Of 117 patients included, 85 experienced blood culture-proven infection. Coagulase-negative staphylococci were responsible for 55% of the episodes. No significant differences were found in cognitive, motor, and behavioral scores or lexiquotient comparing patients with versus no proven infection. When comparing three groups (coagulase-negative staphylococci, other, and negative blood culture), a significant difference was found in composite cognitive scores (p = 0.016), in favor of the coagulase-negative staphylococci group versus other causal agent group (p = 0.007). No significant differences were found in other subscales. Conclusion: In this cohort, no differences were found in neurodevelopmental outcome at 2 years corrected age between proven and no proven infection groups; confirmation in larger cohorts with a control group is needed. Patients encountering coagulase-negative staphylococci sepsis showed a significant better cognitive outcome compared to other causal agents.
引用
收藏
页码:673 / 680
页数:8
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