Analysis of biopharmaceutical proteins in biological matrices by LC-MS/MS I. Sample preparation

被引：25

作者：

Bischoff, Rainer ^{[1
]}

Bronsema, Kees J. ^{[1
,2
]}

van de Merbel, Nico C. ^{[1
,2
]}

机构：

[1] Univ Groningen, Dept Pharm, NL-9713 AV Groningen, Netherlands

[2] PRA Int, Bioanalyt Lab, Early Dev Serv, NL-9405 BJ Assen, Netherlands

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2013年 / 48卷

关键词：

Analytical procedure; Automation; Biological matrix; Biopharmaceuticals; Blood-derived body fluid; Clinical study; Liquid chromatography with tandem mass spectrometry (LC-MS/MS); Pharmacokinetic study; Protein; Sample preparation; PERFORMANCE LIQUID-CHROMATOGRAPHY; PEPTIDE IMMUNOAFFINITY ENRICHMENT; MONITORING MASS-SPECTROMETRY; ABSOLUTE QUANTIFICATION; INTERNAL STANDARD; THERAPEUTIC PROTEINS; MONOCLONAL-ANTIBODY; TRYPSIN DIGESTION; ONLINE; DEAMIDATION;

D O I：

10.1016/j.trac.2012.11.015

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Part I of this review discusses sample-preparation aspects of quantifying biopharmaceutical proteins in complex biological matrices by LC-MS/MS with a focus on blood-derived body fluids. We conclude Part I with a short overview over options for automating the entire analytical procedure, which is indispensable for routine applications in pharmacokinetic and clinical studies. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：41 / 51

页数：11

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