An encapsulation of iron homeostasis and virulence in Cryptococcus neoformans

被引:57
作者
Kronstad, James W. [1 ]
Hu, Guanggan [1 ]
Jung, Won Hee [2 ]
机构
[1] Univ British Columbia, Dept Microbiol & Immunol, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada
[2] Chung Ang Univ, Dept Syst Biotechnol, Anseong 456756, South Korea
基金
加拿大健康研究院; 加拿大自然科学与工程研究理事会; 新加坡国家研究基金会;
关键词
heme; capsule; melanin; virulence; fungal pathogenesis; pH; cell wall; signaling; PROTEIN-KINASE-A; CAPSULE FORMATION; CANDIDA-ALBICANS; FUNGAL PATHOGENESIS; INTRACELLULAR IRON; MURINE MODEL; CHLOROQUINE; ACQUISITION; INFECTION; TRANSCRIPTION;
D O I
10.1016/j.tim.2013.05.007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Vertebrate hosts actively sequester iron, and fungal and other pathogens must therefore adapt to a severe limitation in iron availability to cause disease. Recent studies reveal that the pathogenic fungus Ctyptococcus neoformans overcomes iron limitation by multiple mechanisms that target transferrin and heme. The regulation of iron uptake is mediated by an interconnected set of transcription factors that include the master iron regulator Cir1 and the pH-responsive factor Rim101. These factors integrate iron homeostasis with a myriad of other functions including pH sensing, nutrient and stress signaling pathways, virulence factor elaboration, and cell wall biogenesis.
引用
收藏
页码:457 / 465
页数:9
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