Dicentric translocation (9;12) presenting as refractory Philadelphia chromosome-positive acute B-cell lymphoblastic leukemia

被引：7

作者：

Bargetzi, MJ ^{[1
]}

Mühlematter, D

Tichelli, A

Jotterand, M

Wernli, M

机构：

[1] Kantonsspital Aarau, Ctr Oncol Hematol & Transfus Med, CH-5001 Aarau, Switzerland

[2] Univ Hosp, Div Med Genet, Lausanne, Switzerland

[3] Kantonsspital Basel, Hematol Lab, Basel, Switzerland

来源：

CANCER GENETICS AND CYTOGENETICS | 1999年 / 113卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(98)00284-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 66-year-old Caucasian woman presented with a Philadelphia chromosome positive common B-cell acute lymphoblastic leukemia and a dic(9;12) involving the der(9)t(9;22), a rearrangement so far not observed in acute lymphoblastic leukemia. The patient was treated for the acute lymphoblastic leukemia, but showed refractory disease and died 6 months after initial diagnosis. This case suggests that, in the combination of t(9;22) and dic(9:12), the known poor prognostic feature of t(9;22) in acute lymphoblastic leukemia may outweigh the favorable outcome reported in patients with dic(9:12). (C) Elsevier Science Inc.. 1999; All rights reserved.

引用

页码：90 / 92

页数：3

共 8 条

[1]

BEHRENDT H, 1995, LEUKEMIA, V9, P102

[2]

CARROLL AJ, 1987, BLOOD, V70, P1962

[3] KARYOTYPIC AND CLINICAL FINDINGS IN A CONSECUTIVE SERIES OF CHILDREN WITH ACUTE LYMPHOCYTIC-LEUKEMIA [J].

HEEREMA, NA ;

PALMER, CG ;

BAEHNER, RL .

CANCER GENETICS AND CYTOGENETICS, 1985, 17 (02) :165-179

[4]

HURET JL, 1990, LEUKEMIA, V4, P423

[5]

MAHMOUD H, 1992, LEUKEMIA, V6, P703

[6] ASSOCIATION OF A CHROMOSOMAL-9,12 TRANSLOCATION WITH B-CELL PRECURSOR LYMPHOBLASTIC BLAST CRISIS OF A PH+ CHRONIC MYELOGENOUS LEUKEMIA [J].

SOLARY, E ;

MUGNERET, F ;

GUY, H ;

CAILLOT, D ;

CARLI, PM ;

TURCCAREL, C .

BRITISH JOURNAL OF HAEMATOLOGY, 1989, 72 (01) :106-108

[7]

Stark B, 1996, LEUKEMIA, V10, P183

[8] INTENSIVE INDUCTION/CONSOLIDATION THERAPY WITHOUT MAINTENANCE IN ADULT ACUTE LYMPHOBLASTIC-LEUKEMIA - A PILOT ASSESSMENT [J].

WERNLI, M ;

TICHELLI, A ;

VONFLIEDNER, V ;

DELRE, GB ;

CHAPUIS, B ;

FEY, MF ;

FOPP, M ;

GMUR, J ;

GROB, JP ;

JACKY, E ;

PEDRAZZINI, A ;

SCHMID, L ;

SENN, HJ ;

TOBLER, A ;

GRATWOHL, A .

BRITISH JOURNAL OF HAEMATOLOGY, 1994, 87 (01) :39-43

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