Characterizing the glycome of the mammalian immune system

被引：47

作者：

Haslam, Stuart M.

Julien, Sylvain ^{[2
]}

Burchell, Joy M. ^{[2
]}

Monk, Clare R. ^{[3
]}

Ceroni, Alessio

Garden, Oliver A. ^{[3
,4
]}

Dell, Anne ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Nat Sci, Div Mol Biosci, London SW7 2AZ, England

[2] Kings Coll London, Guys Hosp, Breast Canc Biol Grp, London WC2R 2LS, England

[3] Univ London Imperial Coll Sci Technol & Med, Dept Immunol, Div Med, London, England

[4] Univ London Royal Vet Coll, Dept Vet Clin Sci, Infect & Immun Res Grp, Regulatory T Cell Lab, London, England

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2008年 / 86卷 / 07期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

glycomics; glycoproteins; immune cells; mass-spectrometry;

D O I：

10.1038/icb.2008.54

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The outermost layer of all immune cells, the glycocalyx, is composed of a complex mixture of glycoproteins, glycolipids and lectins, which specifically recognize particular glycan epitopes. As the glycocalyx is the cell's primary interface with the external environment many biologically significant events can be attributed to glycan recognition. For this reason the rapidly expanding glycomics field is being increasingly recognized as an important component in our quest to better understand the functioning of the immune system. In this review, we highlight the current status of immune cell glycomics, with particular attention being paid to T- and B-lymphocytes and dendritic cells. We also describe the strategies and methodologies used to define immune cell glycomes.

引用

页码：564 / 573

页数：10

共 122 条

[1] Signal transduction in the aging immune system [J].