DNA Gridiron Nanostructures Based on Four-Arm Junctions

被引:222
|
作者
Han, Dongran [1 ,2 ]
Pal, Suchetan [1 ,2 ]
Yang, Yang [1 ,2 ]
Jiang, Shuoxing [1 ,2 ]
Nangreave, Jeanette [1 ,2 ]
Liu, Yan [1 ,2 ]
Yan, Hao [1 ,2 ]
机构
[1] Arizona State Univ, Biodesign Inst, Tempe, AZ 85287 USA
[2] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA
基金
美国国家科学基金会;
关键词
FOLDING DNA;
D O I
10.1126/science.1232252
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Engineering wireframe architectures and scaffolds of increasing complexity is one of the important challenges in nanotechnology. We present a design strategy to create gridiron-like DNA structures. A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons were assembled, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects.
引用
收藏
页码:1412 / 1415
页数:4
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