The Functional Heterogeneity of Resident Cardiac Macrophages in Myocardial Injury CCR2+ Cells Promote Inflammation, Whereas CCR2- Cells Protect

被引:34
作者
Chen, Bijun [1 ]
Brickshawana, Adipong [1 ]
Frangogiannis, Nikolaos G. [1 ]
机构
[1] Albert Einstein Coll Med, Dept Med Cardiol, Wilf Family Cardiovasc Res Inst, Bronx, NY 10467 USA
基金
美国国家卫生研究院;
关键词
STEADY-STATE; DIVERGENT; SUBSETS;
D O I
10.1161/CIRCRESAHA.118.314357
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:183 / 185
页数:3
相关论文
共 15 条
[1]   Myocardial Ischemia/Reperfusion Injury Is Mediated by Leukocytic Toll-Like Receptor-2 and Reduced by Systemic Administration of a Novel Anti-Toll-Like Receptor-2 Antibody [J].
Arslan, Fatih ;
Smeets, Mirjam B. ;
O'Neill, Luke A. J. ;
Keogh, Brian ;
McGuirk, Peter ;
Timmers, Leo ;
Tersteeg, Claudia ;
Hoefer, Imo E. ;
Doevendans, Pieter A. ;
Pasterkamp, Gerard ;
de Kleijn, Dominique P. V. .
CIRCULATION, 2010, 121 (01) :80-90
[2]   Tissue Resident CCR2-and CCR2+Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury [J].
Bajpai, Geetika ;
Bredemeyer, Andrea ;
Li, Wenjun ;
Zaitsev, Konstantin ;
Koenig, Andrew L. ;
Lokshina, Inessa ;
Mohan, Jayaram ;
Ivey, Brooke ;
Hsiao, His-Min ;
Weinheimer, Carla ;
Kovacs, Attila ;
Epelman, Slava ;
Artyomov, Maxim ;
Kreisel, Daniel ;
Lavine, Kory J. .
CIRCULATION RESEARCH, 2019, 124 (02) :263-278
[3]   The human heart contains distinct macrophage subsets with divergent origins and functions [J].
Bajpai, Geetika ;
Schneider, Caralin ;
Wong, Nicole ;
Bredemeyer, Andrea ;
Hulsmans, Maarten ;
Nahrendorf, Matthias ;
Epelman, Slava ;
Kreisel, Daniel ;
Liu, Yongjian ;
Itoh, Akinobu ;
Shankar, Thirupura S. ;
Selzman, Craig H. ;
Drakos, Stavros G. ;
Lavine, Kory J. .
NATURE MEDICINE, 2018, 24 (08) :1234-+
[4]   Dual role of CCR2 during initiation and progression of collagen-induced arthritis:: Evidence for regulatory activity of CCR2+ T cells [J].
Brühl, H ;
Cihak, J ;
Schneider, MA ;
Plachy, J ;
Rupp, T ;
Wenzel, I ;
Shakarami, M ;
Milz, S ;
Ellwart, JW ;
Stangassinger, M ;
Schlöndorff, D ;
Mack, M .
JOURNAL OF IMMUNOLOGY, 2004, 172 (02) :890-898
[5]   Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling [J].
Bujak, Marcin ;
Dobaczewski, Marcin ;
Chatila, Khaled ;
Mendoza, Leonardo H. ;
Li, Na ;
Reddy, Anilkumar ;
Frangogiannis, Nikolaos G. .
AMERICAN JOURNAL OF PATHOLOGY, 2008, 173 (01) :57-67
[6]   CCL2/monocyte chemoattractant protein-1 regulates inflammatory responses critical to healing myocardial infarcts [J].
Dewald, O ;
Zymek, P ;
Winkelmann, K ;
Koerting, A ;
Ren, GF ;
Abou-Khamis, T ;
Michael, LH ;
Rollins, BJ ;
Entman, ML ;
Frangogiannis, NG .
CIRCULATION RESEARCH, 2005, 96 (08) :881-889
[7]   Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation [J].
Epelman, Slava ;
Lavine, Kory J. ;
Beaudin, Anna E. ;
Sojka, Dorothy K. ;
Carrero, Javier A. ;
Calderon, Boris ;
Brija, Thaddeus ;
Gautier, Emmanuel L. ;
Ivanov, Stoyan ;
Satpathy, Ansuman T. ;
Schilling, Joel D. ;
Schwendener, Reto ;
Sergin, Ismail ;
Razani, Babak ;
Forsberg, E. Camilla ;
Yokoyama, Wayne M. ;
Unanue, Emil R. ;
Colonna, Marco ;
Randolph, Gwendalyn J. ;
Mann, Douglas L. .
IMMUNITY, 2014, 40 (01) :91-104
[8]   Evidence for an active inflammatory process in the hibernating human myocardium [J].
Frangogiannis, NG ;
Shimoni, S ;
Chang, SM ;
Ren, GF ;
Shan, K ;
Aggeli, C ;
Reardon, MJ ;
Letsou, GV ;
Espada, R ;
Ramchandani, M ;
Entman, ML ;
Zoghbi, WA .
AMERICAN JOURNAL OF PATHOLOGY, 2002, 160 (04) :1425-1433
[9]   The inflammatory response in myocardial injury, repair, and remodelling [J].
Frangogiannis, Nikolaos G. .
NATURE REVIEWS CARDIOLOGY, 2014, 11 (05) :255-265
[10]   Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction [J].
Heidt, Timo ;
Courties, Gabriel ;
Dutta, Partha ;
Sager, Hendrik B. ;
Sebas, Matt ;
Iwamoto, Yoshiko ;
Sun, Yuan ;
Da Silva, Nicolas ;
Panizzi, Peter ;
van der Lahn, Anja M. ;
Swirski, Filip K. ;
Weissleder, Ralph ;
Nahrendorf, Matthias .
CIRCULATION RESEARCH, 2014, 115 (02) :284-295