Radiometals for Combined Imaging and Therapy

被引：320

作者：

Cutler, Cathy S. ^{[1
]}

Hennkens, Heather M. ^{[1
]}

Sisay, Nebiat ^{[1
,2
]}

Huclier-Markai, Sandrine ^{[3
]}

Jurisson, Silvia S. ^{[2
]}

机构：

[1] Univ Missouri, Res Reactor Ctr, Columbia, MO 65211 USA

[2] Univ Missouri, Dept Chem, Columbia, MO 65211 USA

[3] Univ Nantes, Lab Subatech, UMR 6457, Ecole Mines Nantes,CNRS IN2P3, F-44307 Nantes 3, France

来源：

CHEMICAL REVIEWS | 2013年 / 113卷 / 02期

关键词：

POSITRON EMISSION TOMOGRAPHY; METASTATIC BONE PAIN; COPPER-64-LABELED MONOCLONAL-ANTIBODY; PARTICLE-EMITTING RADIONUCLIDES; CLUSTER-LABELED ANTIBODIES; NUCLEAR-MEDICINE THERAPY; RAY CRYSTAL-STRUCTURES; DOTA-BINDING ANTIBODY; SCHIFF-BASE COMPLEXES; IN-VIVO EVALUATION;

D O I：

10.1021/cr3003104

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A study was conducted to demonstrate the use of radiometals for combined imaging and therapy. The study presented radiometals that had the nuclear properties required for use in theranostic applications for imaging and therapy. Their chemistry and production methods were discussed, along with examples of preclinical and clinical uses. A number of radiometals had been evaluated for positron emission tomography (PET) due to their favorable nuclear properties. The choice of type and energy of the particle emission was determined by the size of the lesion or tumor being treated, site of delivery, whether the tumor was homogeneous, and whether the dose was delivered uniformly to each cell. A major advantage of using such nanosized radioactive particles was their potential to contain numerous radioactive atoms within a single nanoparticle.

引用

页码：858 / 883

页数：26

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