Radiometals for Combined Imaging and Therapy

A study was conducted to demonstrate the use of radiometals for combined imaging and therapy. The study presented radiometals that had the nuclear properties required for use in theranostic applications for imaging and therapy. Their chemistry and production methods were discussed, along with examples of preclinical and clinical uses. A number of radiometals had been evaluated for positron emission tomography (PET) due to their favorable nuclear properties. The choice of type and energy of the particle emission was determined by the size of the lesion or tumor being treated, site of delivery, whether the tumor was homogeneous, and whether the dose was delivered uniformly to each cell. A major advantage of using such nanosized radioactive particles was their potential to contain numerous radioactive atoms within a single nanoparticle.