Varicella-Like Cutaneous Toxoplasmosis in a Patient with Aplastic Anemia

被引:5
作者
Zimmermann, Stefan [1 ]
Hadaschik, Eva [2 ,3 ]
Dalpke, Alexander [1 ]
Hassel, Jessica C. [2 ,3 ]
Ajzenberg, Daniel [4 ]
Tenner-Racz, Klara [5 ]
Lehners, Nicola [6 ]
Kapaun, Annette [1 ]
Schnitzler, Paul [1 ]
机构
[1] Heidelberg Univ, Dept Infect Dis, Heidelberg, Germany
[2] Heidelberg Univ, Dept Dermatol, Heidelberg, Germany
[3] Univ Limoges, Ctr Hosp Univ Dupuytren, Ctr Natl Reference Toxoplasmose, Toxoplasma Biol Resource Ctr, Limoges, France
[4] Univ Limoges, INSERM, UMR 1094, Lab Parasitol Mycol,Fac Med, Limoges, France
[5] Bernhard Nocht Inst Trop Med, Hamburg, Germany
[6] Heidelberg Univ, Dept Internal Med, Heidelberg, Germany
关键词
TIME PCR ASSAY; GONDII; AF146527; TRANSPLANTATION; PNEUMONIA; INFECTION; DIAGNOSIS;
D O I
10.1128/JCM.02851-12
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
A 60-year-old patient with aplastic anemia presented with vesicular varicella-like skin lesions on her face, arms, legs, back, and abdomen. However, diagnosis for herpetic infection was negative. Findings of a skin biopsy led to a tentative histologic diagnosis of toxoplasmosis, and infection with Toxoplasma gondii was confirmed by immunohistochemistry and PCR. Cutaneous toxoplasmosis is a rare finding in immunocompromised patients and might mimic other infectious diseases, and vesicular lesions associated with toxoplasmosis have not been reported previously.
引用
收藏
页码:1341 / 1344
页数:4
相关论文
共 24 条
[1]   Genotyping of Toxoplasma gondii Isolates with 15 Microsatellite Markers in a Single Multiplex PCR Assay [J].
Ajzenberg, Daniel ;
Collinet, Frederic ;
Mercier, Aurelien ;
Vignoles, Philippe ;
Darde, Marie-Laure .
JOURNAL OF CLINICAL MICROBIOLOGY, 2010, 48 (12) :4641-4645
[2]   Genotype of 88 Toxoplasma gondii Isolates Associated with Toxoplasmosis in Immunocompromised Patients and Correlation with Clinical Findings [J].
Ajzenberg, Daniel ;
Yera, Helene ;
Marty, Pierre ;
Paris, Luc ;
Dalle, Frederic ;
Menotti, Jean ;
Aubert, Dominique ;
Franck, Jacqueline ;
Bessieres, Marie-Helene ;
Quinio, Dorothee ;
Pelloux, Herve ;
Delhaes, Laurence ;
Desbois, Nicole ;
Thulliez, Philippe ;
Robert-Gangneux, Florence ;
Kauffmann-Lacroix, Catherine ;
Pujol, Sophie ;
Rabodonirina, Meja ;
Bougnoux, Marie-Elisabeth ;
Cuisenier, Bernadette ;
Duhamel, Chantal ;
Duong, Thanh Hai ;
Filisetti, Denis ;
Flori, Pierre ;
Gay-Andrieu, Francoise ;
Pratlong, Francine ;
Nevez, Gilles ;
Totet, Anne ;
Carme, Bernard ;
Bonnabau, Henri ;
Darde, Marie-Laure ;
Villena, Isabelle .
JOURNAL OF INFECTIOUS DISEASES, 2009, 199 (08) :1155-1167
[3]   Cutaneous toxoplasmosis after bone marrow transplantation with molecular confirmation [J].
Amir, Gail ;
Salant, Harold ;
Resnick, Igor B. ;
Karplus, Rebekah .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2008, 59 (05) :781-784
[4]   Severe Acquired Toxoplasmosis Caused by Wild Cycle of Toxoplasma gondii, French Guiana [J].
Carme, Bernard ;
Demar, Magalie ;
Ajzenberg, Daniel ;
Darde, Marie Laure .
EMERGING INFECTIOUS DISEASES, 2009, 15 (04) :656-658
[5]   Variation of B1 Gene and AF146527 Repeat Element Copy Numbers According to Toxoplasma gondii Strains Assessed Using Real-Time Quantitative PCR [J].
Costa, Jean-Marc ;
Bretagne, Stephane .
JOURNAL OF CLINICAL MICROBIOLOGY, 2012, 50 (04) :1452-1454
[6]  
de Medeiros B C, 2001, Transpl Infect Dis, V3, P24, DOI 10.1034/j.1399-3062.2001.003001024.x
[7]   Prevention of toxoplasmosis in transplant patients [J].
Derouin, F. ;
Pelloux, H. .
CLINICAL MICROBIOLOGY AND INFECTION, 2008, 14 (12) :1089-1101
[8]   Human herpes virus co-infection is associated with mortality in HIV-negative patients with Pneumocystis jirovecii pneumonia [J].
Fillatre, P. ;
Chevrier, S. ;
Revest, M. ;
Gacouin, A. ;
Jouneau, S. ;
Leroy, H. ;
Robert-Gangneux, F. ;
Minjolle, S. ;
Le Tulzo, Y. ;
Tattevin, P. .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2013, 32 (02) :189-194
[9]  
Fong MY, 2010, TROP BIOMED, V27, P447
[10]   Diagnosis of Toxoplasmosis after Allogeneic Stem Cell Transplantation: Results of DNA Detection and Serological Techniques [J].
Fricker-Hidalgo, Helene ;
Bulabois, Claude-Eric ;
Brenier-Pinchart, Marie-Pierre ;
Hamidfar, Rebecca ;
Garban, Frederic ;
Brion, Jean-Paul ;
Timsit, Jean-Francois ;
Cahn, Jean-Yves ;
Pelloux, Herve .
CLINICAL INFECTIOUS DISEASES, 2009, 48 (02) :E9-E15