Helical Superstructure of Intermediate Filaments

被引:7
作者
Bouzar, Lila [1 ]
Mueller, Martin Michael [2 ,3 ]
Messina, Rene [2 ]
Noeding, Bernd [4 ]
Koester, Sarah [4 ]
Mohrbach, Herve [2 ,3 ]
Kulic, Igor M. [3 ]
机构
[1] USTHB, Phys Mat Lab, BP 32 El Alia Bab Ezzouar, Algiers 16111, Algeria
[2] Univ Lorraine, Lab Phys & Chim Theor, UMR 7019, 1 Blvd Arago, F-57070 Metz, France
[3] UdS, CNRS, Inst Charles Sadron, 23 Rue Loess,BP 84047, F-67034 Strasbourg 2, France
[4] Univ Goettingen, Inst XRay Phys, Friedrich Hund Pl 1, D-37077 Gottingen, Germany
关键词
DESMIN;
D O I
10.1103/PhysRevLett.122.098101
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
Intermediate filaments are the least explored among the large cytoskeletal elements. We show here that they display conformational anomalies in narrow microfluidic channels. Their unusual behavior can be understood as the consequence of a previously undetected, large-scale helically curved superstructure. Confinement in a channel orders the otherwise soft, strongly fluctuating helical filaments and enhances their structural correlations, giving rise to experimentally detectable, strongly oscillating tangent correlation functions. We propose an explanation for the detected intrinsic curving phenomenon-an elastic shape instability that we call autocoiling. The mechanism involves self-induced filament buckling via a surface stress located at the outside of the cross section. The results agree with ultrastructural findings and rationalize for the commonly observed looped intermediate filament shapes. Beyond curvature, explaining the molecular origin of the detected helical torsion remains an interesting challenge.
引用
收藏
页数:5
相关论文
共 25 条
[1]  
Alberts B., 2002, Molecular Biology of the Cell, V4
[2]  
Amos A., 1991, MOL CYTOSKELETON
[3]   Motorizing fibres with geometric zero-energy modes [J].
Baumann, Arthur ;
Sanchez-Ferrer, Antoni ;
Jacomine, Leandro ;
Martinoty, Philippe ;
Le Houerou, Vincent ;
Ziebert, Falko ;
Kulic, Igor M. .
NATURE MATERIALS, 2018, 17 (06) :523-+
[4]   Nonlinear Loading-Rate-Dependent Force Response of Individual Vimentin Intermediate Filaments to Applied Strain [J].
Block, Johanna ;
Witt, Hannes ;
Candelli, Andrea ;
Peterman, Erwin J. G. ;
Wuite, Gijs J. L. ;
Janshoff, Andreas ;
Koester, Sarah .
PHYSICAL REVIEW LETTERS, 2017, 118 (04)
[5]   Squeezed helical elastica [J].
Bouzar, Lila ;
Muller, Martin Michael ;
Gosselin, Pierre ;
Kulic, Igor M. ;
Mohrbach, Herve .
EUROPEAN PHYSICAL JOURNAL E, 2016, 39 (11)
[6]   CONSTRUCTION OF BACTERIAL FLAGELLA [J].
CALLADINE, CR .
NATURE, 1975, 255 (5504) :121-124
[7]   Helices [J].
Chouaieb, Nadia ;
Goriely, Alain ;
Maddocks, John H. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (25) :9398-9403
[8]  
Friedel J., 1964, International Series of Monographs on Solid State Physics
[9]   Chirality and equilibrium biopolymer bundles [J].
Grason, Gregory M. ;
Bruinsma, Robijn F. .
PHYSICAL REVIEW LETTERS, 2007, 99 (09)
[10]   Intermediate filaments: Molecular structure, assembly mechanism, and integration into functionally distinct intracellular scaffolds [J].
Herrmann, H ;
Aebi, U .
ANNUAL REVIEW OF BIOCHEMISTRY, 2004, 73 :749-789