Induction of Apoptosis and Cell Cycle Arrest in Human Colorectal Carcinoma by Litchi Seed Extract

被引：25
|
作者：
Hsu, Chih-Ping [2 ]
Lin, Chih-Cheng [3 ]
Huang, Chiu-Chen [4 ]
Lin, Yi-Hsien [3 ]
Chou, Jyh-Ching [5 ]
Tsia, Yu-Ting [2 ]
Su, Jhih-Rou [2 ]
Chung, Yuan-Chiang [1 ,6 ]
机构：
[1] Cheng Ching Hosp, Dept Surg, Chung Kang Branch, Taichung 407, Taiwan
[2] Yuanpei Univ, Dept Med Lab Sci & Biotechnol, Hsinchu 30015, Taiwan
[3] Yuanpei Univ, Dept Biotechnol, Hsinchu 30015, Taiwan
[4] China Med Univ Hosp, Dept Anesthesiol, Taichung 40447, Taiwan
[5] Natl Dong Hwa Univ, Dept Nat Resources & Environm Studies, Hualien 97401, Taiwan
[6] Natl Taiwan Univ Hosp, Dept Surg, Taipei 10048, Taiwan
来源：
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2012年
关键词：
FRUIT PERICARP EXTRACT; COLON-CANCER; IN-VITRO; ANTICANCER ACTIVITY; BREAST-CANCER; BCL-2; FAMILY; PROANTHOCYANIDINS; CASPASE-3; BAX; ACTIVATION;
D O I：
10.1155/2012/341479
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The Litchi (Litchi chinensis) fruit products possess rich amounts of flavanoids and proanthocyanidins. Its pericarp has been shown to inhibit breast and liver cancer cell growth. However, the anticolorectal cancer effect of Litchi seed extract has not yet been reported. In this study, the effects of polyphenol-rich Litchi seed ethanol extract (LCSP) on the proliferation, cell cycle, and apoptosis of two colorectal cancer cell lines Colo320DM and SW480 were examined. The results demonstrated that LCSP significantly induced apoptotic cell death in a dose-dependent manner and arrested cell cycle in G2/M in colorectal carcinoma cells. LCSP also suppressed cyclins and elevated the Bax : Bcl-2 ratio and caspase 3 activity. This study provides in vitro evidence that LCSP serves as a potential chemopreventive agent for colorectal cancer.
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页数：7
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