Successful reversal of diabetes by single donor isologous islet transplantation in a mouse model

被引：3

作者：

Leow, CK ^{[1
]}

Gray, DWR ^{[1
]}

Morris, PJ ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP,NUFFIELD DEPT SURG,OXFORD OX3 9DU,ENGLAND

来源：

CELL TRANSPLANTATION | 1997年 / 6卷 / 04期

关键词：

diabetes; islet; transplantation; mouse;

D O I：

10.1016/S0963-6897(97)80001-2

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

A method for isolating mouse islets which consistently gives a high yield with good purity is described. Using a bovine serum albumin gradient, the mean yield of islets per pancreas is 425 (SEM +/- 15) with a consistent purity of over 90%. Single donor to single recipient of islets transplanted under the renal capsule restores normoglycemia in the diabetic recipients within 2 to 5 days of transplantation. (C) 1997 Elsevier Science Inc.

引用

页码：429 / 430

页数：2