Palladium-catalyzed tandem reaction of o-aminophenols, bromoalkynes and isocyanides to give 4-amine-benzo[b][1,4] oxazepines

被引：67

作者：

Liu, Bifu ^{[1
]}

Li, Yibiao ^{[1
]}

Yin, Meizhou ^{[1
]}

Wu, Wanqing ^{[1
]}

Jiang, Huanfeng ^{[1
]}

机构：

[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 93期

基金：

中国国家自然科学基金;

关键词：

PD-C BOND; PHARMACOLOGICAL EVALUATION; MULTICOMPONENT REACTIONS; REGIOSELECTIVE SYNTHESIS; NUCLEOPHILIC-ADDITION; 3-COMPONENT REACTION; DERIVATIVES; INSERTION; HETEROCYCLES; INHIBITION;

D O I：

10.1039/c2cc35802f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A robust route to 4-amine-benzo[b][1,4] oxazepines relying upon a palladium-catalyzed tandem reaction of o-aminophenols, bromoalkynes and isocyanides has been developed. This chemistry presumably proceeds through the migratory insertion of isocyanides into the vinyl-palladium intermediate as a key step.

引用

页码：11446 / 11448

页数：3

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