Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells

被引：151
|
作者：
Laidlaw, Brian J. [1 ]
Cui, Weiguo [1 ]
Amezquita, Robert A. [1 ,2 ]
Gray, Simon M. [1 ]
Guan, Tianxia [1 ]
Lu, Yisi [1 ]
Kobayashi, Yasushi [1 ]
Flavell, Richard A. [1 ,2 ]
Kleinstein, Steven H. [1 ,3 ,4 ]
Craft, Joe [1 ,5 ]
Kaech, Susan M. [1 ,2 ]
机构：
[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06510 USA
[2] Howard Hughes Med Inst, Chevy Chase, MD USA
[3] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA
[4] Yale Univ, Sch Med, Interdepartmental Program Computat Biol & Bioinfo, New Haven, CT 06510 USA
[5] Yale Univ, Sch Med, Dept Internal Med Rheumatol, New Haven, CT 06510 USA
来源：
NATURE IMMUNOLOGY | 2015年 / 16卷 / 08期
基金：
美国国家卫生研究院;
关键词：
PROTECTIVE IMMUNITY; DENDRITIC CELLS; EFFECTOR; INTERLEUKIN-10; EXPRESSION; RESPONSES; FOXP3(+); VIRUS; INFLAMMATION; LIPOPOLYSACCHARIDE;
D O I：
10.1038/ni.3224
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Memory CD8(+) T cells are critical for host defense upon reexposure to intracellular pathogens. We found that interleukin 10 (IL-10) derived from CD4(+) regulatory T cells (T-reg cells) was necessary for the maturation of memory CD8(+) T cells following acute infection with lymphocytic choriomeningitis virus (LCMV). Treg cell-derived IL-10 was most important during the resolution phase, calming inflammation and the activation state of dendritic cells. Adoptive transfer of IL-10-sufficient Treg cells during the resolution phase 'restored' the maturation of memory CD8(+) T cells in IL-10-deficient mice. Our data indicate that Treg cell-derived IL-10 is needed to insulate CD8(+) T cells from inflammatory signals, and reveal that the resolution phase of infection is a critical period that influences the quality and function of developing memory CD8(+) T cells.
引用
收藏
页码：871 / +
页数：11
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