Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells

被引：155

作者：

Laidlaw, Brian J. ^{[1
]}

Cui, Weiguo ^{[1
]}

Amezquita, Robert A. ^{[1
,2
]}

Gray, Simon M. ^{[1
]}

Guan, Tianxia ^{[1
]}

Lu, Yisi ^{[1
]}

Kobayashi, Yasushi ^{[1
]}

Flavell, Richard A. ^{[1
,2
]}

Kleinstein, Steven H. ^{[1
,3
,4
]}

Craft, Joe ^{[1
,5
]}

Kaech, Susan M. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06510 USA

[2] Howard Hughes Med Inst, Chevy Chase, MD USA

[3] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA

[4] Yale Univ, Sch Med, Interdepartmental Program Computat Biol & Bioinfo, New Haven, CT 06510 USA

[5] Yale Univ, Sch Med, Dept Internal Med Rheumatol, New Haven, CT 06510 USA

来源：

NATURE IMMUNOLOGY | 2015年 / 16卷 / 08期

基金：

美国国家卫生研究院;

关键词：

PROTECTIVE IMMUNITY; DENDRITIC CELLS; EFFECTOR; INTERLEUKIN-10; EXPRESSION; RESPONSES; FOXP3(+); VIRUS; INFLAMMATION; LIPOPOLYSACCHARIDE;

D O I：

10.1038/ni.3224

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Memory CD8(+) T cells are critical for host defense upon reexposure to intracellular pathogens. We found that interleukin 10 (IL-10) derived from CD4(+) regulatory T cells (T-reg cells) was necessary for the maturation of memory CD8(+) T cells following acute infection with lymphocytic choriomeningitis virus (LCMV). Treg cell-derived IL-10 was most important during the resolution phase, calming inflammation and the activation state of dendritic cells. Adoptive transfer of IL-10-sufficient Treg cells during the resolution phase 'restored' the maturation of memory CD8(+) T cells in IL-10-deficient mice. Our data indicate that Treg cell-derived IL-10 is needed to insulate CD8(+) T cells from inflammatory signals, and reveal that the resolution phase of infection is a critical period that influences the quality and function of developing memory CD8(+) T cells.

引用

页码：871 / +

页数：11

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