The clinical spectrum of acute graft-versus-host disease

被引:56
作者
Deeg, HJ
Antin, JH
机构
[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA
[2] Dana Farber Canc Inst, Boston, MA 02115 USA
关键词
D O I
10.1053/j.seminhematol.2005.09.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Acute graft-versus-host disease (GVHD), initiated by the reaction of donor T lymphocytes against nonshared recipient antigens, typically leads to a clinical syndrome characterized by cutaneous eruptions and intestinal and hepatic dysfunction. These three organ systems are considered in the clinical grading of acute GVHD. However, other targets may be involved. With conventional transplant conditioning regimens and in vivo prophylaxis, GVHD becomes clinically manifest within 2 to 4 weeks. With reduced-intensity conditioning, the onset of acute GVHD may be delayed until 2 to 3 months after transplantation. Hyperacute GVHD may occur within a week of transplantation after severely human leukocyte antigen (HLA)-mismatched transplants or transplants without GVHD prophylaxis. There is no reliable laboratory test for acute GVHD, and the diagnosis is based on clinical assessment. © 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:24 / 31
页数:8
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