Iron(III)-Catalyzed Highly Regioselective Halogenation of 8-Amidoquinolines in Water

被引：10

作者：

Long, Yang ^{[1
]}

Pan, Lei ^{[1
]}

Zhou, Xiangge ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem, Chengdu 610064, Sichuan, Peoples R China

来源：

MOLECULES | 2019年 / 24卷 / 03期

基金：

中国国家自然科学基金;

关键词：

8-amidoquinoline; iron; catalysis; water; QUINOLINE N-OXIDES; RHODIUM(III)-CATALYZED C-C; METAL-FREE; 8-AMINOQUINOLINE AMIDES; C5-H BROMINATION; SODIUM-HALIDES; H-HALOGENATION; C-8; POSITION; COPPER; ARYLATION;

D O I：

10.3390/molecules24030535

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple protocol of iron(III)-catalyzed halogenation of 8-amidoquinolines in water under mild conditions was developed, affording the 5-halogenlated products in good to excellent yields up to 98%. The reaction mechanism most likely involves a single-electron transfer (SET) process.

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页数：14

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