Ultrasound-assisted synthesis and antimicrobial activity of tetrazole-based pyrazole and pyrimidine derivatives

被引：14

作者：

Dofe, Vidya S. ^{[1
]}

Sarkate, Aniket P. ^{[2
]}

Shaikh, Zarina M. ^{[3
]}

Gill, Charansingh H. ^{[1
]}

机构：

[1] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Aurangabad 431004, Maharashtra, India

[2] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem Technol, Aurangabad 431004, Maharashtra, India

[3] Maulana Azad Coll Arts Sci & Commerce, Dept Microbiol, Aurangabad 431001, Maharashtra, India

来源：

HETEROCYCLIC COMMUNICATIONS | 2018年 / 24卷 / 01期

关键词：

antimicrobial; pyrazole; pyrimidine; tetrazole; ultrasound; AGENTS; INHIBITORS; DESIGN; SERIES; SAR;

D O I：

10.1515/hc-2017-0067

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New tetrazole-based pyrazole and pyrimidine derivatives were synthesized by an ultrasound irradiation method. All compounds were characterized by infrared spectroscopy (IR), H-1 nuclear magnetic resonance (NMR), C-13 NMR, mass spectrometry (MS) and elemental analysis and assessed in vitro for their efficacy as antimicrobial agents against four bacteria (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa) and two fungi (Candida albicans, Aspergillus niger). Compounds 8a, 8e, 9a, 9b and 9e show potent activity against the tested strains compared to the reference drugs chloramphenicol and clotrimazole.

引用

页码：59 / 65

页数：7

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