RUNX1: an emerging therapeutic target for cardiovascular disease

被引：62

作者：

Riddell, Alexandra ^{[1
]}

McBride, Martin ^{[1
]}

Braun, Thomas ^{[2
]}

Nicklin, Stuart A. ^{[1
]}

Cameron, Ewan ^{[3
]}

Loughrey, Christopher M. ^{[1
]}

Martin, Tamara P. ^{[1
]}

机构：

[1] Univ Glasgow, Inst Cardiovasc & Med Sci, British Heart Fdn Glasgow Cardiovasc Res Ctr, 126 Univ Pl, Glasgow G12 8TA, Lanark, Scotland

[2] Max Planck Inst Heart & Lung Res, Ludwigstr 43, D-61231 Bad Nauheim, Germany

[3] Univ Glasgow, Sch Vet Med, Garscube Campus, Glasgow G61 1BD, Lanark, Scotland

来源：

CARDIOVASCULAR RESEARCH | 2020年 / 116卷 / 08期

关键词：

Runx1; Myocardial infarction; Adverse cardiac remodelling; Cardiovascular diseases; Heart failure; Excitation-contraction coupling; Calcium; HYPOXIA-INDUCIBLE FACTOR; NF-KAPPA-B; ADULT MAMMALIAN CARDIOMYOCYTES; SMALL-MOLECULE INHIBITOR; CD4(+) T-CELLS; MYOCARDIAL-INFARCTION; TRANSCRIPTION FACTOR-1; STEM-CELLS; SKELETAL-MUSCLE; HEART-FAILURE;

D O I：

10.1093/cvr/cvaa034

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Runt-related transcription factor-1 (RUNX1), also known as acute myeloid leukaemia 1 protein (AML1), is a member of the core-binding factor family of transcription factors which modulate cell proliferation, differentiation, and survival in multiple systems. It is a master-regulator transcription factor, which has been implicated in diverse signalling pathways and cellular mechanisms during normal development and disease. RUNX1 is best characterized for its indispensable role for definitive haematopoiesis and its involvement in haematological malignancies. However, more recently RUNX1 has been identified as a key regulator of adverse cardiac remodelling following myocardial infarction. This review discusses the role RUNX1 plays in the heart and highlights its therapeutic potential as a target to limit the progression of adverse cardiac remodelling and heart failure.

引用

页码：1410 / 1423

页数：14

共 189 条

[1] RUNX Genes Find a Niche in Stem Cell Biology [J].