Efficacy of novel benznidazole solutions during the experimental infection with Trypanosoma cruzi

被引：9

作者：

Manarin, Romina ^{[1
,2
]}

Lamas, Maria C. ^{[3
,4
]}

Bottasso, Emanuel ^{[1
]}

Serra, Esteban ^{[2
]}

Revelli, Silvia ^{[1
]}

Salomon, Claudio J. ^{[3
,4
]}

机构：

[1] Fac Ciencias Med, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina

[2] IBR CONICET, Inst Biol Mol & Celular Rosario, RA-2000 Rosario, Santa Fe, Argentina

[3] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, Area Tecnol Farmaceut, RA-2000 Rosario, Santa Fe, Argentina

[4] IQUIR CONICET, Inst Quim Rosario, RA-2000 Rosario, Santa Fe, Argentina

来源：

PARASITOLOGY INTERNATIONAL | 2013年 / 62卷 / 01期

关键词：

Chagas' disease; Benznidazole; Soluble formulation; In vivo studies; CHAGAS-DISEASE; SYSTEMS;

D O I：

10.1016/j.parint.2012.09.001

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Chagas' disease is caused by the protozoan parasite Trypanosoma cruzi. About 8 million people throughout Latin America are infected causing approximately 10,000 deaths annually. Benznidazole, available as unique 100 mg tablets in many of the endemic countries, is currently the drug of choice for the specific treatment of this condition. Despite of the large number of pediatric patients infected, there are no commercial liquid dosage forms available to treat this trypanosomiasis. This work showed that novel benznidazole-water-polyethylene glycol 400 solutions are active against T. cruzi in a murine model of Chagas' disease. Present results constitute the first demonstration on the usefulness of benznidazole solutions in infected mice. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：79 / 81

页数：3