Preparation of monodisperse PEG hydrogel microparticles using a microfluidic flow-focusing device

被引：53
作者：
Dang, Trung-Dung [2 ]
Kim, Young Ho [1 ]
Kim, Hwan Gon [2 ]
Kim, Gyu Man [2 ]
机构：
[1] Kyungpook Natl Univ, Res Inst Adv Energy Technol, Taegu 702701, South Korea
[2] Kyungpook Natl Univ, Sch Mech Engn, Taegu 702701, South Korea
来源：
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | 2012年 / 18卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
Flow-focusing device; Microparticles; Hydrogel; PEG; Droplets; PARTICLES; EMULSIFICATION; LITHOGRAPHY; SIZE;
D O I：
10.1016/j.jiec.2012.01.028
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A microfluidic assisted preparation method of nearly monosized poly(ethylene glycol) (PEG) microparticles has been described. Three types of microfluidic flow-focusing devices with different geometries were fabricated using polydimethylsiloxane (PDMS). Microdroplets of PEG hydrogel were successfully prepared in the microfluidic flow-focusing devices by adjusting the flow rates of the continuous phase, namely, mineral oil, and the dispersed phase, viz., hydrogel solution. Then, the microdroplets of PEG hydrogel were cured by UV irradiation. Various experimental conditions pertaining to the geometry of the microfluidic flow-focusing device, flow rates of the dispersed and continuous phases, and concentration of PEG hydrogel solution were investigated and optimized to fabricate monosized PEG hydrogel microparticles. The prepared PEG microparticles were nearly monosized in the range of 40 mu m to 200 mu m in diameter according to the above experimental conditions. Then, PEG hydrogel particles laden with microbeads of 6 mu m diameter were fabricated using the microfluidic flow-focusing devices with the optimized conditions. (c) 2012 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1308 / 1313
页数：6
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  • [1] Formation of dispersions using "flow focusing" in microchannels
    Anna, SL
    Bontoux, N
    Stone, HA
    [J]. APPLIED PHYSICS LETTERS, 2003, 82 (03) : 364 - 366
  • [2] Control of serial microfluidic droplet size gradient by step-wise ramping of flow rates
    Collins, John
    Lee, Abraham Phillip
    [J]. MICROFLUIDICS AND NANOFLUIDICS, 2007, 3 (01) : 19 - 25
  • [3] Capillary threads and viscous droplets in square microchannels
    Cubaud, Thomas
    Mason, Thomas G.
    [J]. PHYSICS OF FLUIDS, 2008, 20 (05)
  • [4] Continuous-flow lithography for high-throughput microparticle synthesis
    Dendukuri, D
    Pregibon, DC
    Collins, J
    Hatton, TA
    Doyle, PS
    [J]. NATURE MATERIALS, 2006, 5 (05) : 365 - 369
  • [5] Ordered and disordered patterns in two-phase flows in microchannels
    Dreyfus, R
    Tabeling, P
    Willaime, H
    [J]. PHYSICAL REVIEW LETTERS, 2003, 90 (14) : 4
  • [6] Controlled production of emulsions and particles by milli- and microfluidic techniques
    Engl, W.
    Backov, R.
    Panizza, P.
    [J]. CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2008, 13 (04) : 206 - 216
  • [7] Droplets Formation and Merging in Two-Phase Flow Microfluidics
    Gu, Hao
    Duits, Michel H. G.
    Mugele, Frieder
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2011, 12 (04) : 2572 - 2597
  • [8] Microfluidic-based synthesis of non-spherical magnetic hydrogel microparticles
    Hwang, Dae Kun
    Dendukuri, Dhananjay
    Doyle, Patrick S.
    [J]. LAB ON A CHIP, 2008, 8 (10) : 1640 - 1647
  • [9] Hydrogel microparticles as dynamically tunable microlenses
    Kim, J
    Serpe, MJ
    Lyon, LA
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (31) : 9512 - 9513
  • [10] Role of geometry and fluid properties in droplet and thread formation processes in planar flow focusing
    Lee, Wingki
    Walker, Lynn M.
    Anna, Shelley L.
    [J]. PHYSICS OF FLUIDS, 2009, 21 (03)
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