Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium

被引：471

作者：

Bhasin, Shalender ^{[1
]}

Travison, Thomas G. ^{[2
,3
]}

Manini, Todd M. ^{[4
]}

Patel, Sheena ^{[5
]}

Pencina, Karol M. ^{[1
]}

Fielding, Roger A. ^{[6
]}

Magaziner, Jay M. ^{[7
]}

Newman, Anne B. ^{[8
]}

Kiel, Douglas P. ^{[2
,3
]}

Cooper, Cyrus ^{[9
]}

Guralnik, Jack M. ^{[7
]}

Cauley, Jane A. ^{[8
]}

Arai, Hidenori ^{[10
]}

Clark, Brian C. ^{[11
]}

Landi, Francesco ^{[12
]}

Schaap, Laura A. ^{[13
]}

Pereira, Suzette L. ^{[14
]}

Rooks, Daniel ^{[15
]}

Woo, Jean ^{[16
]}

Woodhouse, Linda J. ^{[17
]}

Binder, Ellen ^{[18
]}

Brown, Todd ^{[19
]}

Shardell, Michelle ^{[20
]}

Xue, Quian-Li ^{[21
,22
]}

D'Agostino, Ralph B., Sr. ^{[23
]}

Orwig, Denise ^{[7
]}

Gorsicki, Greg ^{[24
]}

Correa-De-Araujo, Rosaly ^{[25
]}

Cawthon, Peggy M. ^{[5
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Boston Claude Pepper Older Amer Independence Ctr, Boston, MA 02115 USA

[2] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA

[3] Harvard Med Sch, Marcus Inst Aging Res, Hebrew SeniorLife, Boston, MA 02115 USA

[4] Univ Florida, Dept Aging & Geriatr Res, Gainesville, FL USA

[5] Calif Pacific Med Ctr, San Francisco Coordinating Ctr, Res Inst, San Francisco, CA USA

[6] Tufts Univ, Nutr Exercise Physiol & Sarcopenia Lab, Jean Mayer US Dept Agr, Human Nutr Res Ctr Aging, Boston, MA 02111 USA

[7] Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth, Baltimore, MD 21201 USA

[8] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA

[9] Univ Southampton, MRC, Lifecourse Epidemiol Unit, Southampton, Hants, England

[10] Natl Ctr Geriatr & Gerontol, Obu, Japan

[11] Ohio Musculoskeletal & Neurol Inst, Div Geriatr Med, Dept Biomed Sci, Athens, OH USA

[12] Univ Cattolica Sacro Cuore, Dept Med & Geriatr, Rome, Italy

[13] Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Hlth Sci, Fac Sci, Amsterdam, Netherlands

[14] Abbott Labs, Abbott Nutr, Chicago, IL USA

[15] Novartis Inst Biomed Res, Translat Med, Muscle Grp, Cambridge, MA USA

[16] Chinese Univ Hong Kong, SH Ho Ctr Gerontol & Geriatr, CUHK Jockey Club Inst Ageing, Shatin, Hong Kong, Peoples R China

[17] Univ Alberta, Fac Rehabil Med, Edmonton, AB, Canada

[18] Washington Univ, Sch Med, Div Geriatr, St Louis, MO USA

[19] Johns Hopkins Univ, Div Endocrinol Diabet & Metab, Baltimore, MD USA

[20] NIA, Epidemiol & Publ Hlth, Longitudinal Studies Sect, Baltimore, MD 21224 USA

[21] Johns Hopkins Med Inst, Div Geriatr Med & Gerontol, Baltimore, MD 21205 USA

[22] Johns Hopkins Med Inst, Ctr Aging & Hlth, Baltimore, MD 21205 USA

[23] Boston Univ, Dept Math, Framingham Heart Study, Boston, MA 02215 USA

[24] Georgia Southern Univ, Dept Kinesiol, Bethesda, MD USA

[25] NIA, Div Geriatr & Clin Gerontol, Bethesda, MD 20892 USA

来源：

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY | 2020年 / 68卷 / 07期

基金：

英国医学研究理事会;

关键词：

sarcopenia; lean mass cut points; grip strength cut points; mobility disability; consensus definition of sarcopenia; PHYSICAL-ACTIVITY; BODY-COMPOSITION; COHORT PROFILE; HIP FRACTURE; OLDER-PEOPLE; GAIT SPEED; HEALTH; RISK; MEN; MORTALITY;

D O I：

10.1111/jgs.16372

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

OBJECTIVES To develop an evidence-based definition of sarcopenia that can facilitate identification of older adults at risk for clinically relevant outcomes (eg, self-reported mobility limitation, falls, fractures, and mortality), the Sarcopenia Definition and Outcomes Consortium (SDOC) crafted a set of position statements informed by a literature review and SDOC's analyses of eight epidemiologic studies, six randomized clinical trials, four cohort studies of special populations, and two nationally representative population-based studies. METHODS Thirteen position statements related to the putative components of a sarcopenia definition, informed by the SDOC analyses and literature synthesis, were reviewed by an independent international expert panel (panel) iteratively and voted on by the panel during the Sarcopenia Position Statement Conference. Four position statements related to grip strength, three to lean mass derived from dual-energy x-ray absorptiometry (DXA), and four to gait speed; two were summary statements. RESULTS The SDOC analyses identified grip strength, either absolute or scaled to measures of body size, as an important discriminator of slowness. Both low grip strength and low usual gait speed independently predicted falls, self-reported mobility limitation, hip fractures, and mortality in community-dwelling older adults. Lean mass measured by DXA was not associated with incident adverse health-related outcomes in community-dwelling older adults with or without adjustment for body size. CONCLUSION The panel agreed that both weakness defined by low grip strength and slowness defined by low usual gait speed should be included in the definition of sarcopenia. These position statements offer a rational basis for an evidence-based definition of sarcopenia. The analyses that informed these position statements are summarized in this article and discussed in accompanying articles in this issue of the journal. J Am Geriatr Soc 68:1410-1418, 2020.

引用

页码：1410 / 1418

页数：9

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