Impact of H-aggregation on activatable MMP-2-specific probes for optical imaging

被引：4

作者：

Lebel, Rejean ^{[1
]}

Bonin, Marc-Andre ^{[1
]}

Zriba, Riadh ^{[1
]}

Radulska, Adrianna ^{[1
]}

Neugebauer, Witold ^{[2
]}

Lepage, Martin ^{[1
]}

机构：

[1] Univ Sherbrooke, Dept Med Nucl & Radiobiol, Ctr Imagerie Mol Sherbrooke, Sherbrooke, PQ J1K 2R1, Canada

[2] Univ Sherbrooke, Dept Pharmacol, Sherbrooke, PQ J1K 2R1, Canada

来源：

CONTRAST MEDIA & MOLECULAR IMAGING | 2012年 / 7卷 / 03期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

MMP-2; QSY; 21; Cy5; Aggregation; NIRF; probe; MATRIX-METALLOPROTEINASE ACTIVATION; ACTIVITY IN-VIVO; CANCER; FLUORESCENCE; PEPTIDE;

D O I：

10.1002/cmmi.500

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In order to target and image MMP-2 activity using optical imaging, we developed a panel of new MMP-2 probes based on Cy5 and QSY21 as fluorophore/quencher FRET partners, separated by various MMP-2 specific peptide substrates. We compared these probes for their specificity against other MMPs, their rate of activation by MMP-2 and their initial quenching. Copyright (c) 2012 John Wiley & Sons, Ltd.

引用

收藏

页码：328 / 337

页数：10

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共 30 条

[21] Tumour microenvironment - Opinion - Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy [J].

Overall, CM ;

Kleifeld, O .

NATURE REVIEWS CANCER, 2006, 6 (03) :227-239

[22] Developing a peptide-based near-infrared molecular probe for protease sensing [J].

Pham, W ;

Choi, YD ;

Weissleder, R ;

Tung, CH .

BIOCONJUGATE CHEMISTRY, 2004, 15 (06) :1403-1407

[23] Optical Imaging of Matrix Metalloproteinase-7 Activity In Vivo Using a Proteolytic Nanobeacon [J].

Scherer, Randy L. ;

VanSaun, Michael N. ;

McIntyre, J. Oliver ;

Matrisian, Lynn M. .

MOLECULAR IMAGING, 2008, 7 (03) :118-131

[24] Imaging matrix metalloproteinases in cancer [J].

Scherer, Randy L. ;

McIntyre, J. Oliver ;

Matrisian, Lynn M. .

CANCER AND METASTASIS REVIEWS, 2008, 27 (04) :679-690

[25] In vivo optical molecular imaging of matrix metalloproteinase activity in abdominal aortic aneurysms correlates with treatment effects on growth rate [J].

Sheth, Rahul A. ;

Maricevich, Marco ;

Mahmood, Umar .

ATHEROSCLEROSIS, 2010, 212 (01) :181-187

[26] Exercise attenuates matrix metalloproteinase activity in preexisting atherosclerotic plaque [J].

Shon, Soo-Min ;

Park, Jong-Ho ;

Nahrendorf, Matthias ;

Schellingerhout, Dawid ;

Kim, Jeong-Yeon ;

Kang, Byeong-Teck ;

Jeong, Sang-Wuk ;

Kim, Eo-Jin ;

Ryu, Ju Hee ;

Kim, Kwangmeyung ;

Kwon, Ick Chan ;

Lee, Dong Kun ;

Lee, Myoung Mook ;

Kim, Dong-Eog .

ATHEROSCLEROSIS, 2011, 216 (01) :67-73

[27] Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling [J].

Su, HL ;

Spinale, FG ;

Dobrucki, LW ;

Song, J ;

Hua, J ;

Sweterlitsch, S ;

Dione, DP ;

Cavaliere, P ;

Chow, C ;

Bourke, BN ;

Hu, XY ;

Azure, M ;

Yalamanchili, P ;

Liu, R ;

Cheesman, EH ;

Robinson, S ;

Edwards, S ;

Sinusas, AJ .

CIRCULATION, 2005, 112 (20) :3157-3167

[28] Matrix Metalloproteinase Activation Predicts Amelioration of Remodeling After Dietary Modification in Injured Arteries [J].

Tavakoli, Sina ;

Razavian, Mahmoud ;

Zhang, Jiasheng ;

Nie, Lei ;

Marfatia, Ravi ;

Dobrucki, Lawrence W. ;

Sinusas, Albert J. ;

Robinson, Simon ;

Edwards, D. Scott ;

Sadeghi, Mehran M. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2011, 31 (01) :102-+

[29] Regulation of matrix metalloproteinase gene expression [J].

Yan, Chunhong ;

Boyd, Douglas D. .

JOURNAL OF CELLULAR PHYSIOLOGY, 2007, 211 (01) :19-26

[30] Molecular Imaging of Activated Matrix Metalloproteinases in Vascular Remodeling [J].

Zhang, Jiasheng ;

Nie, Lei ;

Razavian, Mahmoud ;

Ahmed, Masood ;

Dobrucki, Lawrence W. ;

Asadi, Abolfazl ;

Edwards, D. Scott ;

Azure, Michael ;

Sinusas, Albert J. ;

Sadeghi, Mehran M. .

CIRCULATION, 2008, 118 (19) :1953-1960