Impact of H-aggregation on activatable MMP-2-specific probes for optical imaging

被引：4

作者：

Lebel, Rejean ^{[1
]}

Bonin, Marc-Andre ^{[1
]}

Zriba, Riadh ^{[1
]}

Radulska, Adrianna ^{[1
]}

Neugebauer, Witold ^{[2
]}

Lepage, Martin ^{[1
]}

机构：

[1] Univ Sherbrooke, Dept Med Nucl & Radiobiol, Ctr Imagerie Mol Sherbrooke, Sherbrooke, PQ J1K 2R1, Canada

[2] Univ Sherbrooke, Dept Pharmacol, Sherbrooke, PQ J1K 2R1, Canada

来源：

CONTRAST MEDIA & MOLECULAR IMAGING | 2012年 / 7卷 / 03期

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

MMP-2; QSY; 21; Cy5; Aggregation; NIRF; probe; MATRIX-METALLOPROTEINASE ACTIVATION; ACTIVITY IN-VIVO; CANCER; FLUORESCENCE; PEPTIDE;

D O I：

10.1002/cmmi.500

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In order to target and image MMP-2 activity using optical imaging, we developed a panel of new MMP-2 probes based on Cy5 and QSY21 as fluorophore/quencher FRET partners, separated by various MMP-2 specific peptide substrates. We compared these probes for their specificity against other MMPs, their rate of activation by MMP-2 and their initial quenching. Copyright (c) 2012 John Wiley & Sons, Ltd.

引用

页码：328 / 337

页数：10

共 30 条

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[Anonymous], IN VIVO IMAGING TREA

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