Cost-effectiveness of Japanese encephalitis (JE) immunization in Bali, Indonesia

被引：20

作者：

Liu, Wei ^{[1
]}

Clemens, John D. ^{[1
]}

Kari, Komang ^{[2
]}

Xu, Zhi-Yi ^{[1
,3
]}

机构：

[1] Int Vaccine Inst, Seoul 151818, South Korea

[2] Sanglah Hosp, Dept Pediat, Bali, Indonesia

[3] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China

来源：

VACCINE | 2008年 / 26卷 / 35期

关键词：

immunization program; Japanese encephalitis vaccines; cost-benefit analysis;

D O I：

10.1016/j.vaccine.2008.06.050

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two hypothetical birth cohorts in Bali, each consisting of 100,000 newborns, one immunized with live, attenuated JE vaccine and the other un-immunized, were modeled for JE risk over 11 years. Cumulative JE incidence before JE vaccine introduction was used to represent JE risk in the unvaccinated cohort. Data on vaccine efficacy, vaccination and treatment costs were taken from published papers and surveys. The potential immunization program averted 54 cases, 5 deaths and saved 1224 disability adjusted life years (DALYs) at a net cost of US$ 700 per JE case averted and US$ 31 per DALY saved and thus was highly cost-effective. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：4456 / 4460

页数：5

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