Adoptive immunotherapy for cancer: harnessing the T cell response

被引：1279
作者：
Restifo, Nicholas P. [1 ]
Dudley, Mark E. [1 ]
Rosenberg, Steven A. [1 ]
机构：
[1] NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2012年 / 12卷 / 04期
基金：
美国国家卫生研究院;
关键词：
CHIMERIC ANTIGEN RECEPTOR; VERSUS-HOST-DISEASE; IN-VIVO; METASTATIC MELANOMA; ANTITUMOR-ACTIVITY; TUMOR TREATMENT; GENE-THERAPY; CHEMO-IMMUNOTHERAPY; ESTABLISHED TUMORS; ADVERSE EVENT;
D O I：
10.1038/nri3191
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immunotherapy based on the adoptive transfer of naturally occurring or gene-engineered T cells can mediate tumour regression in patients with metastatic cancer. Here, we discuss progress in the use of adoptively transferred T cells, focusing on how they can mediate tumour cell eradication. Recent advances include more accurate targeting of antigens expressed by tumours and the associated vasculature, and the successful use of gene engineering to re-target T cells before their transfer into the patient. We also describe how new research has helped to identify the particular T cell subsets that can most effectively promote tumour eradication.
引用
收藏
页码：269 / 281
页数：13
相关论文
共 166 条
  • [1] T-cell receptor gene therapy of established tumors in a murine melanoma model
    Abad, John D.
    Wrzensinski, Claudia
    Overwijk, Willem
    De Witte, Moniek A.
    Jorritsma, Annelies
    Hsu, Cary
    Gattinoni, Luca
    Cohen, Cyrille J.
    Paulos, Chrystal M.
    Palmer, Douglas C.
    Haanen, John B. A. G.
    Schumacher, Ton N. M.
    Rosenberg, Steven A.
    Restifo, Nicholas P.
    Morgan, Richard A.
    [J]. JOURNAL OF IMMUNOTHERAPY, 2008, 31 (01) : 1 - 6
  • [2] Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
    Ahmadzadeh, Mojgan
    Johnson, Laura A.
    Heemskerk, Bianca
    Wunderlich, John R.
    Dudley, Mark E.
    White, Donald E.
    Rosenberg, Steven A.
    [J]. BLOOD, 2009, 114 (08) : 1537 - 1544
  • [3] CTdatabase: a knowledge-base of high-throughput and curated data on cancer-testis antigens
    Almeida, Luiz Gonzaga
    Sakabe, Noboru J.
    deOliveira, Alice R.
    Silva, Maria Cristina C.
    Mundstein, Alex S.
    Cohen, Tzeela
    Chen, Yao-Tseng
    Chua, Ramon
    Gurung, Sita
    Gnjatic, Sacha
    Jungbluth, Achim A.
    Caballero, Otavia L.
    Bairoch, Amos
    Kiesler, Eva
    White, Sarah L.
    Simpson, Andrew J. G.
    Old, Lloyd J.
    Camargo, Anamaria A.
    Vasconcelos, Ana Tereza R.
    [J]. NUCLEIC ACIDS RESEARCH, 2009, 37 : D816 - D819
  • [4] Oncogene-Targeting T Cells Reject Large Tumors while Oncogene Inactivation Selects Escape Variants in Mouse Models of Cancer
    Anders, Kathleen
    Buschow, Christian
    Herrmann, Andreas
    Milojkovic, Ana
    Loddenkemper, Christoph
    Kammertoens, Thomas
    Daniel, Peter
    Yu, Hua
    Charo, Jehad
    Blankenstein, Thomas
    [J]. CANCER CELL, 2011, 20 (06) : 755 - 767
  • [5] CD4+CD25+ T regulatory cells, immunotherapy of cancer, and interleukin-2
    Antony, PA
    Restifo, NP
    [J]. JOURNAL OF IMMUNOTHERAPY, 2005, 28 (02) : 120 - 128
  • [6] CD8+T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells
    Antony, PA
    Piccirillo, CA
    Akpinarli, A
    Finkelstein, SE
    Speiss, PJ
    Surman, DR
    Palmer, DC
    Chan, CC
    Klebanoff, CA
    Overwijk, WW
    Rosenberg, SA
    Restifo, NP
    [J]. JOURNAL OF IMMUNOLOGY, 2005, 174 (05) : 2591 - 2601
  • [7] Baeuerle P. A., 2012, CURR PHARM BIOT 0214
  • [8] Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients
    Baitsch, Lukas
    Baumgaertner, Petra
    Devevre, Estelle
    Raghav, Sunil K.
    Legat, Amandine
    Barba, Leticia
    Wieckowski, Sebastien
    Bouzourene, Hanifa
    Deplancke, Bart
    Romero, Pedro
    Rufer, Nathalie
    Speiser, Daniel E.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (06) : 2350 - 2360
  • [9] A decade of exploring the cancer epigenome - biological and translational implications
    Baylin, Stephen B.
    Jones, Peter A.
    [J]. NATURE REVIEWS CANCER, 2011, 11 (10) : 726 - 734
  • [10] Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
    Bendle, Gavin M.
    Linnemann, Carsten
    Hooijkaas, Anna I.
    Bies, Laura
    de Witte, Moniek A.
    Jorritsma, Annelies
    Kaiser, Andrew D. M.
    Pouw, Nadine
    Debets, Reno
    Kieback, Elisa
    Uckert, Wolfgang
    Song, Ji-Ying
    Haanen, John B. A. G.
    Schumacher, Ton N. M.
    [J]. NATURE MEDICINE, 2010, 16 (05) : 565 - U98
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