Adoptive immunotherapy for cancer: harnessing the T cell response

被引：1301

作者：

Restifo, Nicholas P. ^{[1
]}

Dudley, Mark E. ^{[1
]}

Rosenberg, Steven A. ^{[1
]}

机构：

[1] NCI, Surg Branch, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2012年 / 12卷 / 04期

基金：

美国国家卫生研究院;

关键词：

CHIMERIC ANTIGEN RECEPTOR; VERSUS-HOST-DISEASE; IN-VIVO; METASTATIC MELANOMA; ANTITUMOR-ACTIVITY; TUMOR TREATMENT; GENE-THERAPY; CHEMO-IMMUNOTHERAPY; ESTABLISHED TUMORS; ADVERSE EVENT;

D O I：

10.1038/nri3191

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunotherapy based on the adoptive transfer of naturally occurring or gene-engineered T cells can mediate tumour regression in patients with metastatic cancer. Here, we discuss progress in the use of adoptively transferred T cells, focusing on how they can mediate tumour cell eradication. Recent advances include more accurate targeting of antigens expressed by tumours and the associated vasculature, and the successful use of gene engineering to re-target T cells before their transfer into the patient. We also describe how new research has helped to identify the particular T cell subsets that can most effectively promote tumour eradication.

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收藏

页码：269 / 281

页数：13

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