The emerging role of CXC chemokines and their receptors in cancer

被引：9

作者：

Vinader, Victoria ^{[1
]}

Afarinkia, Kamyar ^{[1
]}

机构：

[1] Inst Canc Therapeut, Bradford BD7 1DP, W Yorkshire, England

来源：

FUTURE MEDICINAL CHEMISTRY | 2012年 / 4卷 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

SQUAMOUS-CELL CARCINOMA; SMALL-MOLECULE ANTAGONISTS; LIGAND BIOLOGICAL AXIS; IN-VITRO; COLON-CARCINOMA; TUMOR-GROWTH; MIG CXCL9; NEUROBLASTOMA-CELLS; GENE-THERAPY; PROMOTES ANGIOGENESIS;

D O I：

10.4155/FMC.12.48

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemokines and their receptors have a multifaceted role in tumor biology and are implicated in nearly all aspects of cancer growth, survival and dissemination. Modulation of the interaction between chemokines and their cell surface receptor is, therefore, a promising area for the development of new cancer medicines. In this review, we look at the compelling evidence that is emerging to support targeting CXC chemokines, also known as family chemokines, as novel therapeutic strategies in the treatment of cancer.

引用

页码：853 / 867

页数：15