Transcription: Tantalizing times for T cells

被引：199
作者：
Ho, IC
Glimcher, LH
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
来源：
CELL | 2002年 / 109卷
关键词：
D O I：
10.1016/S0092-8674(02)00705-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The T helper lymphocyte is responsible for orchestrating an appropriate immune response to pathogens. To do so, it has evolved into two specialized subsets that direct type 1 and type 2 immunity. Here, we discuss the genetic programs that control lineage commitment of progenitor T helper cells along each of these pathways.
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页码：S109 / S120
页数：12
相关论文
共 108 条
[1]   Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation [J].
Agarwal, S ;
Rao, A .
IMMUNITY, 1998, 9 (06) :765-775
[2]   Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo [J].
Agarwal, S ;
Avni, O ;
Rao, A .
IMMUNITY, 2000, 12 (06) :643-652
[3]  
Aronica MA, 1999, J IMMUNOL, V163, P5116
[4]   Eta-1 (osteopontin): An early component of type-1 (cell-mediated) immunity [J].
Ashkar, S ;
Weber, GF ;
Panoutsakopoulou, V ;
Sanchirico, ME ;
Jansson, M ;
Zawaideh, S ;
Rittling, SR ;
Denhardt, DT ;
Glimcher, MJ ;
Cantor, H .
SCIENCE, 2000, 287 (5454) :860-864
[5]   Distinct patterns of membrane microdomain partitioning in Th1 and Th2 cells [J].
Balamuth, F ;
Leitenberg, D ;
Unternaehrer, J ;
Mellman, I ;
Bottomly, K .
IMMUNITY, 2001, 15 (05) :729-738
[6]   Helper T cell differentiation is controlled by the cell cycle [J].
Bird, JJ ;
Brown, DR ;
Mullen, AC ;
Moskowitz, NH ;
Mahowald, MA ;
Sider, JR ;
Gajewski, TF ;
Wang, CR ;
Reiner, SL .
IMMUNITY, 1998, 9 (02) :229-237
[7]   Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells [J].
Bix, M ;
Locksley, RM .
SCIENCE, 1998, 281 (5381) :1352-1354
[8]   Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s [J].
Bonecchi, R ;
Bianchi, G ;
Bordignon, PP ;
D'Ambrosio, D ;
Lang, R ;
Borsatti, A ;
Sozzani, S ;
Allavena, P ;
Gray, PA ;
Mantovani, A ;
Sinigaglia, F .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (01) :129-134
[9]   Cyclic AMP activates p38 mitogen-activated protein kinase in Th2 cells: Phosphorylation of GATA-3 and stimulation of Th2 cytokine gene expression [J].
Chen, CH ;
Zhang, DH ;
LaPorte, JM ;
Ray, A .
JOURNAL OF IMMUNOLOGY, 2000, 165 (10) :5597-5605
[10]   Induction of TH1 and TH2 CD4+ T cell responses: The alternative approaches [J].
Constant, SL ;
Bottomly, K .
ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :297-322
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