Childhood asthma: recent developments and update

被引：11

作者：

Mantzouranis, Eva ^{[1
]}

Papadopouli, Eva ^{[1
]}

Michailidi, Eleni ^{[1
]}

机构：

[1] Univ Hosp, Dept Pediat, Iraklion, Crete, Greece

来源：

CURRENT OPINION IN PULMONARY MEDICINE | 2014年 / 20卷 / 01期

关键词：

asthma phenotypes; atopy; childhood asthma; epigenetics; genetics; GENOME-WIDE ASSOCIATION; MILD PERSISTENT ASTHMA; PRESCHOOL-CHILDREN; INHALED CORTICOSTEROIDS; ALLERGIC SENSITIZATION; GENETIC-VARIANTS; RISK; PHENOTYPES; WHEEZE; EXPOSURE;

D O I：

10.1097/MCP.0000000000000014

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Purpose of reviewThe purpose of this review is to provide an update on childhood asthma specifically related to the underlying genetic background and pathophysiology of asthma and their interaction with environmental stimuli. We will also discuss emerging data in the field of disease phenotyping.Recent findingsThe field of genetics is continuously evolving to expand our knowledge on the cause of disease. Childhood onset asthma has been related to atopy and exposure to early-life infections. More recently, phenotypes have been used to classify asthma as transient and persistent, but the association of each phenotype with the genetic origin of asthma is not clearly understood.SummaryThis review covers the topics of genetics, epigenetics, pathophysiology, phenotypes and treatment as they relate to childhood asthma. Overall, it provides a basis for the future of asthma treatment through description of the current research.

引用

页码：8 / 16

页数：9

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