Synthesis, structural characterization, cytotoxicity in vitro, and effect on DNA of sulfate-trans-dichloro-trans-bis(dimethylsulfoxide)-trans-dimethyl-tin(IV)

被引：5

作者：

Jimenez-Perez, Victor M. ^{[1
]}

Munoz-Flores, Blanca M. ^{[1
]}

Gomez, Alberto ^{[1
]}

Kharisov, Boris ^{[1
]}

Santillan, Rosa ^{[2
]}

Ochoa, Maria E. ^{[2
]}

Blanco Jerez, Leonor M. ^{[1
]}

Garcia, Concepcion ^{[1
]}

Waksman, Noemi ^{[3
]}

Ramirez, Rosalba ^{[3
]}

机构：

[1] Univ Autonoma Nuevo Leon, Fac Ciencias Quim, San Nicolas De Los Garza 66451, NL, Mexico

[2] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Quim, Mexico City 07000, DF, Mexico

[3] Univ Autonoma Nuevo Leon, Fac Med, Monterrey 64460, NL, Mexico

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2014年 / 1058卷

关键词：

Organotin; Sulfate; X-ray; DNA interaction; BIS(TRIMETHYLTIN) SULFATE DIHYDRATE; CRYSTAL-STRUCTURES; ANTITUMOR-ACTIVITY; ORGANOTIN COMPOUNDS; COMPLEXES; DERIVATIVES; MOTIFS; ESTERS; ACIDS; 1D;

D O I：

10.1016/j.molstruc.2013.10.013

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The trans-dichloro-trans-bis(dimethylsulfoxide)-trans-dimethyl-tin(IV) resulted from the reaction of dimethyl-tin(IV) dichloride and sodium sulfate in dimethylsulfoxide (DMSO). The tin compound was characterized by IR, NMR, FE-SEM, EDS, and single crystal X-ray diffraction studies. Suitable DMSO single crystals were obtained after 7 months by slow evaporation at room temperature. The crystal structure has a polymeric arrangement with eight-membered rings as a result of intermolecular coordination S=O -> Sn. The tin atom has an octahedral distorted geometry where the DMSO molecule is coordinated, and also has an infinite arrangement in 2D. Cytotoxicity against A431 cancer cells and MOLT4 leukemic cells and the DNA interaction of the organotin compound were determined. The organotin sulfate derivative showed low biological activity because of the polymeric structure and the saturated tin coordination capability. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：9 / 13

页数：5

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